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Rabbit Anti-CIRBP Recombinant Antibody (D1M8D) (CBMAB-CP0315-LY)

The product is antibody recognizes CIRBP. The antibody D1M8D immunoassay techniques such as: WB,IP.
See all CIRBP antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
D1M8D
Antibody Isotype
IgG
Application
WB, IP

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly150 of human CIRBP protein.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
100 µg/ml BSA, 50% glycerol
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Cold Inducible RNA Binding Protein
Introduction
CIRBP (Cold Inducible RNA Binding Protein) is a Protein Coding gene. Diseases associated with CIRBP include Cryptorchidism, Unilateral Or Bilateral. Among its related pathways are DNA Damage and Translational Control. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is RBMX.
Entrez Gene ID
1153
UniProt ID
Q14011
Alternative Names
Cold Inducible RNA Binding Protein; Cold-Inducible RNA-Binding Protein; Glycine-Rich RNA Binding Protein; A18 HnRNP; CIRP; Glycine-Rich RNA-Binding Protein CIRP; Cold Inducible RNA-Binding Protein; Testicular Tissue Protein Li 39; A18HNRNP;
Function
Cold-inducible mRNA binding protein that plays a protective role in the genotoxic stress response by stabilizing transcripts of genes involved in cell survival. Acts as a translational activator. Seems to play an essential role in cold-induced suppression of cell proliferation. Binds specifically to the 3'-untranslated regions (3'-UTRs) of stress-responsive transcripts RPA2 and TXN. Acts as a translational repressor (By similarity).

Promotes assembly of stress granules (SGs), when overexpressed.
Biological Process
mRNA stabilization Source: UniProtKB
Positive regulation of mRNA splicing, via spliceosome Source: GO_Central
Positive regulation of translation Source: UniProtKB
Response to cold Source: ProtInc
Response to UV Source: UniProtKB
Stress granule assembly Source: UniProtKB
Cellular Location
Cytoplasm; Nucleoplasm. Translocates from the nucleus to the cytoplasm after exposure to UV radiation. Translocates from the nucleus to the cytoplasm into stress granules upon various cytoplasmic stresses, such as osmotic and heat shocks. Its recruitment into stress granules occurs in the absence of TIAR proteins (By similarity).
PTM
Methylated on arginine residues. Methylation of the RGG motifs is a prerequisite for recruitment into SGs (By similarity).
Phosphorylated by CK2, GSK3A and GSK3B. Phosphorylation by GSK3B increases RNA-binding activity to the TXN 3'-UTR transcript upon exposure to UV radiation.

Fujita, Y., Yago, T., Asano, T., Matsumoto, H., Matsuoka, N., Temmoku, J., ... & Migita, K. (2021). Clinical relevance for circulating cold-inducible RNA-binding protein (CIRP) in patients with adult-onset Still’s disease. PloS one, 16(8), e0255493.

Ode, Y., Aziz, M., Jin, H., Arif, A., Nicastro, J. G., & Wang, P. (2019). Cold-inducible RNA-binding protein induces neutrophil extracellular traps in the lungs during sepsis. Scientific reports, 9(1), 1-11.

Hoekstra, M. M., Emmenegger, Y., Hubbard, J., & Franken, P. (2019). Cold-inducible RNA-binding protein (CIRBP) adjusts clock-gene expression and REM-sleep recovery following sleep deprivation. Elife, 8, e43400.

Liu, P., Yao, R., Shi, H., Liu, Y., Lian, S., Yang, Y., ... & Li, S. (2019). Effects of cold-inducible RNA-binding protein (CIRP) on liver glycolysis during acute cold exposure in C57BL/6 mice. International journal of molecular sciences, 20(6), 1470.

Lujan, D. A., Ochoa, J. L., & Hartley, R. S. (2018). Cold‐inducible RNA binding protein in cancer and inflammation. Wiley Interdisciplinary Reviews: RNA, 9(2), e1462.

Roilo, M., Kullmann, M. K., & Hengst, L. (2018). Cold-inducible RNA-binding protein (CIRP) induces translation of the cell-cycle inhibitor p27Kip1. Nucleic acids research, 46(6), 3198-3210.

McGinn, J., Zhang, F., Aziz, M., Yang, W. L., Nicastro, J., Coppa, G. F., & Wang, P. (2018). The protective effect of a short peptide derived from cold-inducible RNA-binding protein in renal ischemia-reperfusion injury. Shock (Augusta, Ga.), 49(3), 269.

Liao, Y., Tong, L., Tang, L., & Wu, S. (2017). The role of cold‐inducible RNA binding protein in cell stress response. International journal of cancer, 141(11), 2164-2173.

Zhong, P., & Huang, H. (2017). Recent progress in the research of cold-inducible RNA-binding protein. Future science OA, 3(4), FSO246.

Khan, M. M., Yang, W. L., Brenner, M., Bolognese, A. C., & Wang, P. (2017). Cold-inducible RNA-binding protein (CIRP) causes sepsis-associated acute lung injury via induction of endoplasmic reticulum stress. Scientific reports, 7(1), 1-13.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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