CKAP4

CKAP4 (Cytoskeleton Associated Protein 4) is a Protein Coding gene. Diseases associated with CKAP4 include Cystitis and Epispadias. Among its related pathways are Innate Immune System and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include signal transducer activity.

Full Name

Cytoskeleton Associated Protein 4

Function

Mediates the anchoring of the endoplasmic reticulum to microtubules.

High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.

Biological Process

Cellular protein metabolic process Source: Reactome
Neutrophil degranulation Source: Reactome
Post-translational protein modification Source: Reactome

Cellular Location

Endoplasmic reticulum membrane; Cytoskeleton; Cell membrane; Perinuclear region. Translocates to the perinuclear region upon APF-stimulation.

Topology

Cytoplasmic: 1-106
Helical: 107-127
Extracellular: 128-602

PTM

Reversibly palmitoylated. Palmitoylation at Cys-100 by ZDHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Palmitoylation by ZDHHC2 is also required for its function in APF-mediated antiproliferative signaling (PubMed:19144824).
Increased phosphorylation during mitosis prevents binding to microtubules.

Anti-CKAP4 antibodies

Mouse Anti-CKAP4 Recombinant Antibody (CBFYC-1880) (CBMAB-C1945-FY)

Datasheet

SDS

Target: CKAP4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBFYC-1880

Application*: IP, IF

Mouse Anti-CKAP4 Recombinant Antibody (G1/296) (CBMAB-C3827WJ)

Datasheet

SDS

Target: CKAP4

Host: Mouse

Antibody Isotype: IgG2a

Specificity: Human, Monkey

Clone: G1/296

Application*: E, F, IC, IH, IP, WB

Mouse Anti-CKAP4 Recombinant Antibody (1.1_2F4) (CBMAB-C1949-LY)

Datasheet

SDS

Target: CKAP4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 1.1_2F4

Application*: IP, IC/IF

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)