CKAP4

CKAP4 (Cytoskeleton Associated Protein 4) is a Protein Coding gene. Diseases associated with CKAP4 include Cystitis and Epispadias. Among its related pathways are Innate Immune System and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include signal transducer activity.

Full Name

Cytoskeleton Associated Protein 4

Function

Mediates the anchoring of the endoplasmic reticulum to microtubules.

High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.

Biological Process

Cellular protein metabolic process Source: Reactome
Neutrophil degranulation Source: Reactome
Post-translational protein modification Source: Reactome

Cellular Location

Endoplasmic reticulum membrane; Cytoskeleton; Cell membrane; Perinuclear region. Translocates to the perinuclear region upon APF-stimulation.

Topology

Cytoplasmic: 1-106
Helical: 107-127
Extracellular: 128-602

PTM

Reversibly palmitoylated. Palmitoylation at Cys-100 by ZDHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Palmitoylation by ZDHHC2 is also required for its function in APF-mediated antiproliferative signaling (PubMed:19144824).
Increased phosphorylation during mitosis prevents binding to microtubules.