CKAP4

CKAP4 (Cytoskeleton Associated Protein 4) is a Protein Coding gene. Diseases associated with CKAP4 include Cystitis and Epispadias. Among its related pathways are Innate Immune System and Protein processing in endoplasmic reticulum. Gene Ontology (GO) annotations related to this gene include signal transducer activity.
Full Name
Cytoskeleton Associated Protein 4
Function
Mediates the anchoring of the endoplasmic reticulum to microtubules.

High-affinity epithelial cell surface receptor for the FZD8-related low molecular weight sialoglycopeptide APF/antiproliferative factor. Mediates the APF antiproliferative signaling within cells.
Biological Process
Cellular protein metabolic process Source: Reactome
Neutrophil degranulation Source: Reactome
Post-translational protein modification Source: Reactome
Cellular Location
Endoplasmic reticulum membrane; Cytoskeleton; Cell membrane; Perinuclear region. Translocates to the perinuclear region upon APF-stimulation.
Topology
Cytoplasmic: 1-106
Helical: 107-127
Extracellular: 128-602
PTM
Reversibly palmitoylated. Palmitoylation at Cys-100 by ZDHHC2 is required for its trafficking from the ER to the plasma membrane and for its perinuclear localization. Palmitoylation by ZDHHC2 is also required for its function in APF-mediated antiproliferative signaling (PubMed:19144824).
Increased phosphorylation during mitosis prevents binding to microtubules.
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Anti-CKAP4 antibodies

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Mouse Anti-CKAP4 Recombinant Antibody (C1949) (CBMAB-C1949-LY)

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Target: CKAP4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: C1949
Application*: E
Datasheet SDS

Human CKAP4 ELISA Kit (V2LY-0626-LY4211)

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Target: CKAP4
Sensitivity: 0.0069 ng/mL
Detection Range: 0.015-3 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Rabbit Anti-CKAP4 Recombinant Antibody (C3827) (CBMAB-C3827WJ)

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Target: CKAP4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey
Clone: C3827
Application*: WB, IF, P
Datasheet SDS

Mouse Anti-CKAP4 Recombinant Antibody (CBFYC-1880) (CBMAB-C1945-FY)

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Target: CKAP4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBFYC-1880
Application*: WB, IP, IF, E, P
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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