CYP26A1

CYP26A1 (Cytochrome P450 Family 26 Subfamily A Member 1) is a Protein Coding gene. Diseases associated with CYP26A1 include Acute Promyelocytic Leukemia and Mixed Germ Cell Cancer. Among its related pathways are Metabolism and Cytochrome P450 - arranged by substrate type. Gene Ontology (GO) annotations related to this gene include iron ion binding and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen. An important paralog of this gene is CYP26C1.

Full Name

Cytochrome P450 Family 26 Subfamily A Member 1

Function

A cytochrome P450 monooxygenase involved in the metabolism of all-trans retinoic acid (atRA), a signaling molecule that binds to retinoic acid receptors and regulates gene transcription. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase). Catalyzes the hydroxylation of carbon hydrogen bonds of atRA primarily at C-4 and C-18. Has no activity toward 9-cis and 13-cis retinoic acid stereoisomers (PubMed:22020119, PubMed:9228017, PubMed:9716180).

May play a role in the oxidative metabolism of xenobiotics such as tazarotenic acid (PubMed:26937021).

Biological Process

Kidney development Source: Ensembl
Negative regulation of retinoic acid receptor signaling pathway Source: BHF-UCL
Response to retinoic acid Source: Ensembl
Response to vitamin A Source: Ensembl
Retinoic acid catabolic process Source: BHF-UCL
Retinoic acid metabolic process Source: UniProtKB
Sterol metabolic process Source: GO_Central
Vitamin metabolic process Source: Reactome
Xenobiotic metabolic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane; Microsome membrane