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DAP3

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Splice variants that differ in the 5' UTR have been found for this gene; both variants encode the same protein. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq]

Full Name

death associated protein 3

Function

Involved in mediating interferon-gamma-induced cell death.

Biological Process

Apoptotic signaling pathway Source: ProtInc
Mitochondrial translational elongation Source: Reactome
Mitochondrial translational termination Source: Reactome

Cellular Location

Mitochondrion

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Anti-DAP3 antibodies

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Mouse Anti-DAP3 Recombinant Antibody (D0213) (V2LY-0125-LY1091)

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Target: DAP3

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Mouse

Clone: D0213

Application*: WB

Mouse Anti-DAP3 Recombinant Antibody (D0210) (V2LY-0125-LY1090)

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Target: DAP3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: D0210

Application*: WB, IP, IF, E

Mouse Anti-DAP3 Recombinant Antibody (1A12) (V2LY-0125-LY1089)

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Target: DAP3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: 1A12

Application*: WB, IP, IF, E

Mouse Anti-DAP3 Recombinant Antibody (D0206) (V2LY-0125-LY1088)

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Target: DAP3

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: D0206

Application*: WB, IP, IF, E

Mouse Anti-DAP3 Recombinant Antibody (3B7) (V2LY-0125-LY1087)

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Target: DAP3

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 3B7

Application*: WB, E

Mouse Anti-DAP3 Recombinant Antibody (D0202) (V2LY-0125-LY1086)

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Target: DAP3

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: D0202

Application*: WB, IP, IF, E

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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