DEPTOR

DEPTOR (DEP Domain Containing MTOR Interacting Protein) is a Protein Coding gene. Among its related pathways are Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics and Development HGF signaling pathway.

Full Name

DEP Domain Containing MTOR Interacting Protein

Function

Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.

Biological Process

Intracellular signal transduction Source: InterPro
Negative regulation of cell size Source: UniProtKB
Negative regulation of protein kinase activity Source: UniProtKB
Negative regulation of TOR signaling Source: UniProtKB
Regulation of extrinsic apoptotic signaling pathway Source: UniProtKB

PTM

Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.
Ubiquitinated; ubiquitination leads to proteasomal degradation.

Anti-DEPTOR antibodies

Mouse Anti-DEPTOR Recombinant Antibody (5B3) (CBMAB-A2189-LY)

Datasheet

SDS

Target: DEPTOR

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 5B3

Application*: SE, E

Mouse Anti-DEPTOR Recombinant Antibody (D-2) (CBMAB-D0708-YC)

Datasheet

SDS

Target: DEPTOR

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: D-2

Application*: WB, IP, IF, E

Rabbit Anti-DEPTOR Recombinant Antibody (D9F5) (CBMAB-D0709-YC)

Datasheet

SDS

Target: DEPTOR

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Rat, Monkey

Clone: D9F5

Application*: WB, IP, P

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)