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Mouse Anti-DEPTOR Recombinant Antibody (D-2) (CBMAB-D0708-YC)

Provided herein is a Mouse monoclonal antibody, which binds to DEP Domain Containing MTOR Interacting Protein (DEPTOR). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all DEPTOR antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
D-2
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
DEP Domain Containing MTOR Interacting Protein
Introduction
DEPTOR (DEP Domain Containing MTOR Interacting Protein) is a protein coding gene. Among its related pathways are Sirolimus Pathway, Pharmacokinetics/Pharmacodynamics and Development HGF signaling pathway.
Entrez Gene ID
64798
UniProt ID
Q8TB45
Alternative Names
DEP Domain Containing MTOR Interacting Protein; DEP Domain-Containing Protein 6; DEP Domain Containing 6; DEPDC6; DEP Domain-Containing MTOR-Interacting Protein; DEP.6;
Function
Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.
Biological Process
Intracellular signal transduction Source: InterPro
Negative regulation of cell size Source: UniProtKB
Negative regulation of protein kinase activity Source: UniProtKB
Negative regulation of TOR signaling Source: UniProtKB
Regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
PTM
Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.
Ubiquitinated; ubiquitination leads to proteasomal degradation.

Wälchli, M., Berneiser, K., Mangia, F., Imseng, S., Craigie, L. M., Stuttfeld, E., ... & Maier, T. (2021). Regulation of human mTOR complexes by DEPTOR. Elife, 10, e70871.

Perez-Tejeiro, J. M., & Csukasi, F. (2021). DEPTOR in Skeletal Development and Diseases. Frontiers in Genetics, 12.

Heimhalt, M., Berndt, A., Wagstaff, J., Anandapadamanaban, M., Perisic, O., Maslen, S., ... & Williams, R. L. (2021). Bipartite binding and partial inhibition links DEPTOR and mTOR in a mutually antagonistic embrace. Elife, 10, e68799.

Chen, S., Jia, L., Zhang, S., Zheng, Y., & Zhou, Y. (2018). DEPTOR regulates osteogenic differentiation via inhibiting MEG3-mediated activation of BMP4 signaling and is involved in osteoporosis. Stem Cell Research & Therapy, 9(1), 1-14.

Varusai, T. M., & Nguyen, L. K. (2018). Dynamic modelling of the mTOR signalling network reveals complex emergent behaviours conferred by DEPTOR. Scientific reports, 8(1), 1-14.

Wang, Q., Zhou, Y., Rychahou, P., Harris, J. W., Zaytseva, Y. Y., Liu, J., ... & Evers, B. M. (2018). Deptor is a novel target of Wnt/β-catenin/c-Myc and contributes to colorectal cancer cell growth. Cancer research, 78(12), 3163-3175.

Chen, H., Shen, F., Sherban, A., Nocon, A., Li, Y., Wang, H., ... & Zang, M. (2018). DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute‐on‐chronic liver injury in alcoholic liver disease. Hepatology, 68(2), 496-514.

Caron, A., Briscoe, D. M., Richard, D., & Laplante, M. (2018). DEPTOR at the nexus of cancer, metabolism, and immunity. Physiological reviews, 98(3), 1765-1803.

Catena, V., & Fanciulli, M. (2017). Deptor: not only a mTOR inhibitor. Journal of Experimental & Clinical Cancer Research, 36(1), 1-9.

Caron, A., Mouchiroud, M., Gautier, N., Labbé, S. M., Villot, R., Turcotte, L., ... & Laplante, M. (2017). Loss of hepatic DEPTOR alters the metabolic transition to fasting. Molecular metabolism, 6(5), 447-458.

Hu, Y., Su, H., Liu, C., Wang, Z., Huang, L., Wang, Q., ... & Qing, G. (2017). DEPTOR is a direct NOTCH1 target that promotes cell proliferation and survival in T-cell leukemia. Oncogene, 36(8), 1038-1047.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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