DOCK1

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Dedicator Of Cytokinesis 1

Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).

Apoptotic process Source: ProtInc
Integrin-mediated signaling pathway Source: ProtInc
Phagocytosis, engulfment Source: ProtInc
Positive regulation of epithelial cell migration Source: UniProtKB
Positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Signal transduction Source: ProtInc
Small GTPase mediated signal transduction Source: ProtInc

Cytoplasm; Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate.