DOCK1

This gene encodes a member of the dedicator of cytokinesis protein family. Dedicator of cytokinesis proteins act as guanine nucleotide exchange factors for small Rho family G proteins. The encoded protein regulates the small GTPase Rac, thereby influencing several biological processes, including phagocytosis and cell migration. Overexpression of this gene has also been associated with certain cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Full Name
Dedicator Of Cytokinesis 1
Function
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).
Biological Process
Apoptotic process Source: ProtInc
Integrin-mediated signaling pathway Source: ProtInc
Phagocytosis, engulfment Source: ProtInc
Positive regulation of epithelial cell migration Source: UniProtKB
Positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Signal transduction Source: ProtInc
Small GTPase mediated signal transduction Source: ProtInc
Cellular Location
Cytoplasm; Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate.
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Anti-DOCK1 antibodies

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Mouse Anti-DOCK1 Recombinant Antibody (3D10) (CBMAB-D1474-YC)

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Target: DOCK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D10
Application*: E, WB
Datasheet SDS

Rabbit Anti-DOCK1 Recombinant Antibody (H.398.0) (CBMAB-D1473-YC)

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Target: DOCK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: H.398.0
Application*: IP, WB
Datasheet SDS

Mouse Anti-DOCK1 Recombinant Antibody (E-2) (CBMAB-D1471-YC)

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Target: DOCK1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: E-2
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DOCK1 Recombinant Antibody (D1473) (V2LY-0425-LY764)

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Target: DOCK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: D1473
Application*: WB, IP, IF, E, P
Datasheet SDS

Mouse Anti-DOCK1 Recombinant Antibody (D1471) (V2LY-0425-LY763)

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Target: DOCK1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: D1471
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-DOCK1 Recombinant Antibody (EG984) (V2LY-0425-LY766)

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Target: DOCK1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse, Rat
Clone: EG984
Application*: WB
Datasheet SDS

Mouse Anti-DOCK1 Recombinant Antibody (3D10) (V2LY-0425-LY765)

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Target: DOCK1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 3D10
Application*: E, WB
Datasheet SDS

Rabbit Anti-DOCK1 Recombinant Antibody (EG984) (CBMAB-EN1166-LY)

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Target: DOCK1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: EG984
Application*: WB: 1:500~1:1000 ELISA: 1:40000
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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