Search :
Sign in or Register  
Welcome Sign in or Don't have an account?Register

Mouse Anti-DOCK1 Recombinant Antibody (3D10) (V2LY-0425-LY765)


See all DOCK1 antibodies
Online Inquiry

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D10
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
DOCK1 (aa698-803) partial recombinant protein.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal Antibody

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
None
Concentration
Batch dependent
Purity
>95% as determined by analysis by SDS-PAGE
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Dedicator Of Cytokinesis 1
Entrez Gene ID
1793
UniProt ID
Q14185
Function
Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1, mediates CRK/CRKL regulation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed:19004829).

Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed:8657152).
Biological Process
Apoptotic process Source: ProtInc
Integrin-mediated signaling pathway Source: ProtInc
Phagocytosis, engulfment Source: ProtInc
Positive regulation of epithelial cell migration Source: UniProtKB
Positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKB
Signal transduction Source: ProtInc
Small GTPase mediated signal transduction Source: ProtInc
Cellular Location
Cytoplasm; Membrane. Recruited to membranes via its interaction with phosphatidylinositol 3,4,5-trisphosphate.
More Infomation

Yang, X., Wang, Y., Pang, S., Li, X., Wang, P., Ma, R., ... & Song, C. (2021). LINC00665 promotes the progression of acute myeloid leukemia by regulating the miR-4458/DOCK1 pathway. Scientific reports, 11(1), 1-16.

Cui, W., & Xue, J. (2020). Circular RNA DOCK1 downregulates microRNA‐124 to induce the growth of human thyroid cancer cell lines. Biofactors, 46(4), 591-599.

Liu, P., Li, X., Guo, X., Chen, J., Li, C., Chen, M., ... & Zu, X. (2019). Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa‐miR‐132‐3p/Sox5 signalling pathway. Cell proliferation, 52(4), e12614.

Chiang, S. K., Chang, W. C., Chen, S. E., & Chang, L. C. (2019). DOCK1 regulates growth and motility through the RRP1B-claudin-1 pathway in claudin-low breast cancer cells. Cancers, 11(11), 1762.

Tomino, T., Tajiri, H., Tatsuguchi, T., Shirai, T., Oisaki, K., Matsunaga, S., ... & Uruno, T. (2018). DOCK1 inhibition suppresses cancer cell invasion and macropinocytosis induced by self-activating Rac1P29S mutation. Biochemical and biophysical research communications, 497(1), 298-304.

Liang, Y., Wang, S., & Zhang, Y. (2018). Downregulation of Dock1 and Elmo1 suppresses the migration and invasion of triple‑negative breast cancer epithelial cells through the RhoA/Rac1 pathway. Oncology Letters, 16(3), 3481-3488.

Cunningham, R. L., Herbert, A. L., Harty, B. L., Ackerman, S. D., & Monk, K. R. (2018). Mutations in dock1 disrupt early Schwann cell development. Neural development, 13(1), 1-15.

Zhang, B., Li, H., Yin, C., Sun, X., Zheng, S., Zhang, C., ... & Lu, S. (2017). Dock1 promotes the mesenchymal transition of glioma and is modulated by MiR‐31. Neuropathology and Applied Neurobiology, 43(5), 419-432.

Tajiri, H., Uruno, T., Shirai, T., Takaya, D., Matsunaga, S., Setoyama, D., ... & Fukui, Y. (2017). Targeting Ras-driven cancer cell survival and invasion through selective inhibition of DOCK1. Cell reports, 19(5), 969-980.

Lee, S. H., Chiu, Y. C., Li, Y. H., Lin, C. C., Hou, H. A., Chou, W. C., & Tien, H. F. (2017). High expression of dedicator of cytokinesis 1 (DOCK1) confers poor prognosis in acute myeloid leukemia. Oncotarget, 8(42), 72250.

Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-DOCK1 Recombinant Antibody (3D10)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Learn more

Documents

Request bulk or custom quote Online Inquiry
Second antibody and isotype control

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Online Inquiry