EAF2
EAF2 has properties characteristic for an RNA polymerase II elongation factor regulating the expression of the eye‐specific transcription factor Rx.
Full Name
ELL associated factor 2
Research Area
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity).
Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of cell growth Source: Ensembl
Negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription elongation from RNA polymerase II promoter Source: ARUK-UCL
Negative regulation of cell growth Source: Ensembl
Negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription elongation from RNA polymerase II promoter Source: ARUK-UCL
Cellular Location
Nucleus speckle
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Anti-EAF2 antibodies
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Target: EAF2
Host: Rabbit
Specificity: Human
Clone: E1R8C
Application*: WB, IP, CI
Target: EAF2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: E0695
Application*: WB, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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