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Rabbit Anti-EAF2 Recombinant Antibody (E1R8C) (CBMAB-E0695-FY)

This product is rabbit antibody that recognizes EAF2. The antibody E1R8C can be used for immunoassay techniques such as: WB, IP, ChIP.
See all EAF2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
E1R8C
Application
WB, IP, ChIP

Basic Information

Specificity
Human
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
ELL associated factor 2
Introduction
EAF2 has properties characteristic for an RNA polymerase II elongation factor regulating the expression of the eye‐specific transcription factor Rx.
Entrez Gene ID
55840
UniProt ID
Q96CJ1
Alternative Names
U19; BM040; TRAITS
Research Area
Acts as a transcriptional transactivator of TCEA1 elongation activity (By similarity).

Acts as a transcriptional transactivator of ELL and ELL2 elongation activities. Potent inducer of apoptosis in prostatic and non-prostatic cell lines. Inhibits prostate tumor growth in vivo.
Biological Process
Apoptotic process Source: UniProtKB-KW
Negative regulation of cell growth Source: Ensembl
Negative regulation of epithelial cell proliferation involved in prostate gland development Source: Ensembl
Positive regulation of transcription by RNA polymerase II Source: NTNU_SB
Regulation of transcription elongation from RNA polymerase II promoter Source: ARUK-UCL
Cellular Location
Nucleus speckle

Pascal, L. E., Rigatti, L. H., Ai, J., Zhang, A., Zhou, J., Nelson, J. B., & Wang, Z. (2020). EAF2 loss induces prostatic intraepithelial neoplasia from luminal epithelial cells in mice. American journal of clinical and experimental urology, 8(1), 18.

Wn, K., Guo, F., Yc, F., Lv, J., Jh, F., Wang, Y., ... & Xm, M. (2020). Expression and gene regulation network of EAF2 in cervical cancer based on data mining.

Liu, R., Chen, C., Li, Y., Huang, Q., & Xue, Y. (2020). ELL-associated factors EAF1/2 negatively regulate HIV-1 transcription through inhibition of Super Elongation Complex formation. Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms, 1863(5), 194508.

Jo, Y. S., Kim, S. S., Kim, M. S., Yoo, N. J., & Lee, S. H. (2019). Candidate tumor suppressor gene EAF2 is mutated in colorectal and gastric cancers. Pathology & Oncology Research, 25(2), 823-824.

Feng, K., & Guo, H. K. (2018). Eaf2 protects human lens epithelial cells against oxidative stress‑induced apoptosis by Wnt signaling. Molecular medicine reports, 17(2), 2795-2802.

Yang, T., Jing, Y., Dong, J., Yu, X., Zhong, M., Pascal, L. E., ... & Wang, Z. (2018). Regulation of ELL2 stability and polyubiquitination by EAF2 in prostate cancer cells. The Prostate, 78(15), 1201-1212.

Zhong, M., Pascal, L. E., Cheng, E., Masoodi, K. Z., Chen, W., Green, A., ... & Wang, Z. (2018). Concurrent EAF2 and ELL2 loss phenocopies individual EAF2 or ELL2 loss in prostate cancer cells and murine prostate. American journal of clinical and experimental urology, 6(6), 234.

Zhong, M., Pascal, L., Song, Q., Chen, W., & Wang, Z. (2018, November). ELL2 and EAF2 co-regulation of AKT in prostate cancer cells. In Endocrine Abstracts (Vol. 59). Bioscientifica.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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