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EBF2

EBF2 (Early B Cell Factor 2) is a Protein Coding gene. The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. Diseases associated with EBF2 include Inguinal Hernia and Kallmann Syndrome.

Full Name

early B cell factor 2

Research Area

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).

Biological Process

Adipose tissue development Source: Ensembl
Brown fat cell differentiation Source: Ensembl
Cell fate determination Source: Ensembl
Positive regulation of chromatin binding Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

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Anti-EBF2 antibodies

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Mouse Anti-EBF2 Recombinant Antibody (CBWJN-0808) (CBMAB-N0287-WJ)

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Target: EBF2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Mouse, Rat, Horse, Dog, Cattle, Pig

Clone: CBWJN-0808

Application*: WB, IP, IF, E, P

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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