EBF2

EBF2 (Early B Cell Factor 2) is a Protein Coding gene. The protein encoded by this gene belongs to the COE (Collier/Olf/EBF) family of non-basic, helix-loop-helix transcription factors that have a well conserved DNA binding domain. Diseases associated with EBF2 include Inguinal Hernia and Kallmann Syndrome.

Full Name

early B cell factor 2

Research Area

Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognizes variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3' (By similarity).

Biological Process

Adipose tissue development Source: Ensembl
Brown fat cell differentiation Source: Ensembl
Cell fate determination Source: Ensembl
Positive regulation of chromatin binding Source: Ensembl
Positive regulation of cold-induced thermogenesis Source: YuBioLab
Regulation of transcription by RNA polymerase II Source: GO_Central

Cellular Location

Nucleus

Anti-EBF2 antibodies

Mouse Anti-EBF2 Recombinant Antibody (CBWJN-0808) (CBMAB-N0287-WJ)

Datasheet

SDS

Target: EBF2

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBWJN-0808

Application*: IH, WB

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)