EIF4E2

EIF4E2 (Eukaryotic Translation Initiation Factor 4E Family Member 2) is a Protein Coding gene. Among its related pathways are Cytokine Signaling in Immune system and Transport of the SLBP independent Mature mRNA. Gene Ontology (GO) annotations related to this gene include ubiquitin protein ligase binding. An important paralog of this gene is EIF4E.

Full Name

eukaryotic translation initiation factor 4E family member 2

Research Area

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation (PubMed:17368478, PubMed:25624349, PubMed:9582349).

Acts as a repressor of translation initiation (PubMed:22751931).

In contrast to EIF4E, it is unable to bind eIF4G (EIF4G1, EIF4G2 or EIF4G3), suggesting that it acts by competing with EIF4E and block assembly of eIF4F at the cap (By similarity).

In P-bodies, component of a complex that promotes miRNA-mediated translational repression (PubMed:28487484).

Biological Process

Gene silencing by RNA Source: UniProtKB-KW
Negative regulation of translation Source: MGI
Positive regulation of miRNA mediated inhibition of translation Source: UniProtKB

Cellular Location

Cytoplasm; P-body

PTM

Ubiquitinated by ARIH1 (PubMed:14623119, PubMed:25624349). The consequences of ubiquitination are however unclear: according to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report ubiquitination leads to its subsequent degradation (PubMed:14623119).
ISGylation enhances its cap structure-binding activity and translation-inhibition activity.