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FAF1

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]
Full Name
Fas Associated Factor 1
Research Area
Ubiquitin-binding protein (PubMed:19722279).

Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564).

Potentiates but cannot initiate FAS-induced apoptosis (By similarity).
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell death Source: UniProtKB
Cytoplasmic sequestering of NF-kappaB Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cell death Source: CACAO
Positive regulation of cellular protein catabolic process Source: UniProtKB
Positive regulation of DNA replication Source: UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Positive regulation of protein-containing complex assembly Source: UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of cell adhesion Source: Ensembl
Regulation of protein catabolic process Source: UniProtKB
Cellular Location
Nucleus

Anti-FAF1 antibodies

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Target: FAF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-2824
Application*: E, IF, WB
Target: FAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CF160
Application*: ELISA, WB
Target: FAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 904
Application*: ELISA, WB
Target: FAF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1166
Application*: WB: 1:500~1:1000 ELISA: 1:1000
Target: FAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2499
Application*: WB, IH
Target: FAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-2497
Application*: WB
Target: FAF1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1126
Application*: WB, IP, P, F, IF
Target: FAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: CBXF-2234
Application*: E, WB, IR
Target: FAF1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBXF-2825
Application*: E, WB
Target: FAF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1G6
Application*: WB, E
Target: FAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6BA8
Application*: E, WB
Target: FAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 6BA9
Application*: E, WB
Target: FAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXF-0268
Application*: E, WB
Target: FAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3668
Application*: WB, IH
Target: FAF1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-3648
Application*: WB
Target: FAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-3657
Application*: WB
Target: FAF1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBXF-1461
Application*: IH
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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