FAF1

Interaction of Fas ligand (TNFSF6) with the FAS antigen (TNFRSF6) mediates programmed cell death, also called apoptosis, in a number of organ systems. The protein encoded by this gene binds to FAS antigen and can initiate apoptosis or enhance apoptosis initiated through FAS antigen. Initiation of apoptosis by the protein encoded by this gene requires a ubiquitin-like domain but not the FAS-binding domain. [provided by RefSeq, Jul 2008]
Full Name
Fas Associated Factor 1
Research Area
Ubiquitin-binding protein (PubMed:19722279).

Required for the progression of DNA replication forks by targeting DNA replication licensing factor CDT1 for degradation (PubMed:26842564).

Potentiates but cannot initiate FAS-induced apoptosis (By similarity).
Biological Process
Apoptotic process Source: UniProtKB-KW
Cell death Source: UniProtKB
Cytoplasmic sequestering of NF-kappaB Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of cell death Source: CACAO
Positive regulation of cellular protein catabolic process Source: UniProtKB
Positive regulation of DNA replication Source: UniProtKB
Positive regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Ensembl
Positive regulation of protein-containing complex assembly Source: UniProtKB
Proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
Regulation of cell adhesion Source: Ensembl
Regulation of protein catabolic process Source: UniProtKB
Cellular Location
Nucleus
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Anti-FAF1 antibodies

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Mouse Anti-FAF1 Monoclonal Antibody (1220) (V2LY-0825-LY1289)

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Target: FAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1220
Application*: E, WB
Datasheet SDS

Mouse Anti-FAF1 Recombinant Antibody (904) (CBMAB-AP2189LY)

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Target: FAF1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 904
Application*: WB, IH
Datasheet SDS

Mouse Anti-FAF1 Recombinant Antibody (CBXF-3648) (CBMAB-F2884-CQ)

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Target: FAF1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-3648
Application*: E, WB
Datasheet SDS

Mouse Anti-FAF1 Recombinant Antibody (CBXF-3668) (CBMAB-F2740-CQ)

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Target: FAF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBXF-3668
Application*: E, WB, IF
Datasheet SDS

Mouse Anti-FAF1 Recombinant Antibody (CBXF-0268) (CBMAB-F2661-CQ)

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Target: FAF1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-0268
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FAF1 Recombinant Antibody (CBXF-2234) (CBMAB-F1145-CQ)

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Target: FAF1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Mouse, Rat
Clone: CBXF-2234
Application*: WB, IP, IF, E
Datasheet SDS

Mouse Anti-FAF1 Recombinant Antibody (CBXF-2499) (CBMAB-F0708-CQ)

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Target: FAF1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBXF-2499
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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