FARP1

This gene was originally isolated through subtractive hybridization due to its increased expression in differentiated chondrocytes versus dedifferentiated chondrocytes. The resulting protein contains a predicted ezrin-like domain, a Dbl homology domain, and a pleckstrin homology domain. It is believed to be a member of the band 4.1 superfamily whose members link the cytoskeleton to the cell membrane. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq]

FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)

Functions as guanine nucleotide exchange factor for RAC1. May play a role in semaphorin signaling. Plays a role in the assembly and disassembly of dendritic filopodia, the formation of dendritic spines, regulation of dendrite length and ultimately the formation of synapses (By similarity).

Dendrite morphogenesis Source: UniProtKB
Postsynaptic actin cytoskeleton organization Source: Ensembl
Regulation of presynapse assembly Source: Ensembl
Retrograde trans-synaptic signaling by trans-synaptic protein complex Source: Ensembl
Synapse assembly Source: UniProtKB

Cytosol; Cell membrane; Synapse; Synaptosome; Filopodium; Dendrite; Dendritic spine. Recruited to the cell membrane via interaction with CADM1.