FRY

FRY (FRY Microtubule Binding Protein) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include binding. An important paralog of this gene is FRYL.

Full Name

FRY Microtubule Binding Protein

Function

Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.

Biological Process

Cell morphogenesis Source: GO_Central
Negative regulation of tubulin deacetylation Source: Ensembl
Neuron projection development Source: GO_Central

Cellular Location

Cytoplasm; Centrosome; Spindle pole. Distributed diffusely throughout the cytoplasm in interphase. Localizes to the separating centrosomes in prophase, to the spindle poles and spindle microtubules in prometaphase to metaphase, to spindle microtubules in anaphase and to the distal sections of the midbody in cytokinesis. Colocalizes with PLK1 to separating centrosomes and spindle poles from prophase to metaphase in mitosis, but not in other stages of the cell cycle.

PTM

Phosphorylated by AURKA, CDK1 and PLK1.