FZD8

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Full Name
Frizzled Class Receptor 8
Function
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Biological Process
Canonical Wnt signaling pathway Source: WormBase
Neuron differentiation Source: UniProtKB
Cellular Location
Golgi apparatus; Cell membrane; Membrane. Colocalizes with GOPC at the Golgi apparatus.
Topology
Extracellular: 28-275
Helical: 276-296
Cytoplasmic: 297-312
Helical: 313-333
Extracellular: 334-396
Helical: 397-417
Cytoplasmic: 418-439
Helical: 440-460
Extracellular: 461-483
Helical: 484-504
Cytoplasmic: 505-532
Helical: 533-553
Extracellular: 554-584
Helical: 585-605
Cytoplasmic: 606-694
PTM
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
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Anti-FZD8 antibodies

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Rat Anti-FZD8 Recombinant Antibody (CBXF-1687) (CBMAB-F4163-CQ)

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Target: FZD8
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXF-1687
Application*: WB
Datasheet SDS

Rabbit Anti-FZD8 Recombinant Antibody (CBXF-1242) (CBMAB-F1012-CQ)

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Target: FZD8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBXF-1242
Application*: WB, P
Datasheet SDS

Rat Anti-FZD8 Recombinant Antibody (CBXF-2191) (CBMAB-F0709-CQ)

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Target: FZD8
Host: Rat
Antibody Isotype: IgG2
Specificity: Mouse
Clone: CBXF-2191
Application*: WB
Datasheet SDS

Rat Anti-FZD8 (Extracellular domain) Recombinant Antibody (CBXF-0996) (CBMAB-F0480-CQ)

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Target: FZD8
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-0996
Application*: E, WB
Datasheet SDS

Rabbit Anti-FZD8 Recombinant Antibody (EG1259) (V2LY-1225-LY418)

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Target: FZD8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1259
Application*: WB, IH
Datasheet SDS

Mouse Anti-FZD8 Recombinant Antibody (CBXF-1687) (V2LY-1225-LY417)

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Target: FZD8
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBXF-1687
Application*: IF
Datasheet SDS

Rabbit Anti-FZD8 Recombinant Antibody (CBXF-1242) (V2LY-1225-LY416)

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Target: FZD8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse
Clone: CBXF-1242
Application*: WB, P
Datasheet SDS

Rat Anti-FZD8 Recombinant Antibody (CBXF-2191) (V2LY-1225-LY415)

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Target: FZD8
Host: Rat
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBXF-2191
Application*: WB
Datasheet SDS

Mouse Anti-FZD8 Recombinant Antibody (CBXF-0996) (V2LY-1225-LY414)

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Target: FZD8
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBXF-0996
Application*: E
Datasheet SDS

Rabbit Anti-FZD8 Recombinant Antibody (EG1259) (CBMAB-EN1522-LY)

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Target: FZD8
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1259
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:5000
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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