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Rat Anti-FZD8 Recombinant Antibody (CBXF-1687) (CBMAB-F4163-CQ)

This product is a rat antibody that recognizes FZD8. The antibody CBXF-1687 can be used for immunoassay techniques such as: WB.
See all FZD8 antibodies

Summary

Host Animal
Rat
Specificity
Mouse
Clone
CBXF-1687
Antibody Isotype
IgG2
Application
WB

Basic Information

Immunogen
Recombinant protein corresponding to mouse Frizzled-8
Specificity
Mouse
Antibody Isotype
IgG2
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Buffer
Lyophilized from a 0.2 μm filtered solution in PBS
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Frizzled Class Receptor 8
Introduction
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.
Entrez Gene ID
14370
UniProt ID
Q61091
Alternative Names
Frizzled Class Receptor 8; Frizzled 8, Seven Transmembrane Spanning Receptor; Frizzled Family Receptor 8; FZ-8; HFZ8; Frizzled (Drosophila) Homolog 8; Frizzled Homolog 8 (Drosophila); Frizzled Homolog 8; Frizzled-8;
Function
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Biological Process
Canonical Wnt signaling pathway Source: WormBase
Neuron differentiation Source: UniProtKB
Cellular Location
Golgi apparatus; Cell membrane; Membrane. Colocalizes with GOPC at the Golgi apparatus.
Topology
Extracellular: 28-275
Helical: 276-296
Cytoplasmic: 297-312
Helical: 313-333
Extracellular: 334-396
Helical: 397-417
Cytoplasmic: 418-439
Helical: 440-460
Extracellular: 461-483
Helical: 484-504
Cytoplasmic: 505-532
Helical: 533-553
Extracellular: 554-584
Helical: 585-605
Cytoplasmic: 606-694
PTM
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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