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Rabbit Anti-FZD8 Recombinant Antibody (EG1259) (V2LY-1225-LY418)

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Datasheet
SDS
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Basic Information

Host Animal
Rabbit
Clone
EG1259
Application
WB, IHC
Immunogen
Human FZD8.
Host Species
Rabbit
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
ApplicationNote
WB1:1,000-1:2,000
IHC1:100-1:200

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, BSA, glycerol
Preservative
Sodium azide
Concentration
1 mg/ml
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
More Infomation

Target

Full Name
Frizzled Class Receptor 8
Entrez Gene ID
Human8325
Mouse14370
Rat364754
UniProt ID
HumanQ9H461
MouseQ61091
RatQ498S8
Function
Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.
Biological Process
Canonical Wnt signaling pathway Source: WormBase
Neuron differentiation Source: UniProtKB
Cellular Location
Golgi apparatus; Cell membrane; Membrane. Colocalizes with GOPC at the Golgi apparatus.
Topology
Extracellular: 28-275
Helical: 276-296
Cytoplasmic: 297-312
Helical: 313-333
Extracellular: 334-396
Helical: 397-417
Cytoplasmic: 418-439
Helical: 440-460
Extracellular: 461-483
Helical: 484-504
Cytoplasmic: 505-532
Helical: 533-553
Extracellular: 554-584
Helical: 585-605
Cytoplasmic: 606-694
PTM
Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.
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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rabbit Anti-FZD8 Recombinant Antibody (EG1259) (CAT#: CBMAB-EN1522-LY)

Related Products

Rabbit Anti-FZD8 Recombinant Antibody (CBXF-1242) (CAT#: CBMAB-F1012-CQ)

Rat Anti-FZD8 Recombinant Antibody (CBXF-2191) (CAT#: V2LY-1225-LY415)

Mouse Anti-FZD8 Recombinant Antibody (CBXF-1687) (CAT#: V2LY-1225-LY417)

Rat Anti-FZD8 Recombinant Antibody (CBXF-2191) (CAT#: CBMAB-F0709-CQ)

Rabbit Anti-FZD8 Recombinant Antibody (EG1259) (CAT#: CBMAB-EN1522-LY)

Mouse Anti-FZD8 Recombinant Antibody (CBXF-0996) (CAT#: V2LY-1225-LY414)

Rat Anti-FZD8 Recombinant Antibody (CBXF-1687) (CAT#: CBMAB-F4163-CQ)

Rat Anti-FZD8 (Extracellular domain) Recombinant Antibody (CBXF-0996) (CAT#: CBMAB-F0480-CQ)

Rabbit Anti-FZD8 Recombinant Antibody (CBXF-1242) (CAT#: V2LY-1225-LY416)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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