Mouse Anti-FZD8 Recombinant Antibody (CBXF-1687) (V2LY-1225-LY417)

Name: Mouse Anti-FZD8 Recombinant Antibody (CBXF-1687)
SKU: V2LY-1225-LY417
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBXF-1687

Application

Immunogen

Recombinant human Frizzled-8 (Ala25-Pro172).

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

Application	Note
IF(ICC)	8-25 µg/ml

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Lyophilized

Buffer

PBS, trehalose

Preservative

None

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Frizzled Class Receptor 8

Entrez Gene ID

8325

UniProt ID

Q9H461

Function

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Biological Process

Canonical Wnt signaling pathway Source: WormBase
Neuron differentiation Source: UniProtKB

Cellular Location

Golgi apparatus; Cell membrane; Membrane. Colocalizes with GOPC at the Golgi apparatus.

Topology

Extracellular: 28-275
Helical: 276-296
Cytoplasmic: 297-312
Helical: 313-333
Extracellular: 334-396
Helical: 397-417
Cytoplasmic: 418-439
Helical: 440-460
Extracellular: 461-483
Helical: 484-504
Cytoplasmic: 505-532
Helical: 533-553
Extracellular: 554-584
Helical: 585-605
Cytoplasmic: 606-694

PTM

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Rat Anti-FZD8 Recombinant Antibody (CBXF-1687) (CAT#: CBMAB-F4163-CQ)

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Rabbit Anti-FZD8 Recombinant Antibody (EG1259) (CAT#: V2LY-1225-LY418)

Rabbit Anti-FZD8 Recombinant Antibody (CBXF-1242) (CAT#: CBMAB-F1012-CQ)

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Rat Anti-FZD8 Recombinant Antibody (CBXF-2191) (CAT#: V2LY-1225-LY415)

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Rat Anti-FZD8 Recombinant Antibody (CBXF-2191) (CAT#: CBMAB-F0709-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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