Rabbit Anti-FZD8 Recombinant Antibody (CBXF-1242) (CBMAB-F1012-CQ)

Name: Rabbit Anti-FZD8 Recombinant Antibody (CBXF-1242)
SKU: CBMAB-F1012-CQ
Rating: 5 (1 reviews)

See all FZD8 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXF-1242

Application

WB, IHC-P

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Frizzled Class Receptor 8

Introduction

This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the Wingless type MMTV integration site family of signaling proteins. Most frizzled receptors are coupled to the beta-catenin canonical signaling pathway. This gene is highly expressed in two human cancer cell lines, indicating that it may play a role in several types of cancer. The crystal structure of the extracellular cysteine-rich domain of a similar mouse protein has been determined.

Entrez Gene ID

Human	8325
Mouse	14370
Rat	364754

UniProt ID

Human	Q9H461
Mouse	Q61091
Rat	Q498S8

Alternative Names

Frizzled Class Receptor 8; Frizzled 8, Seven Transmembrane Spanning Receptor; Frizzled Family Receptor 8; FZ-8; HFZ8; Frizzled (Drosophila) Homolog 8; Frizzled Homolog 8 (Drosophila); Frizzled Homolog 8; Frizzled-8;

Function

Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1.

Biological Process

Canonical Wnt signaling pathway Source: WormBase
Neuron differentiation Source: UniProtKB

Cellular Location

Golgi apparatus; Cell membrane; Membrane. Colocalizes with GOPC at the Golgi apparatus.

Topology

Extracellular: 28-275
Helical: 276-296
Cytoplasmic: 297-312
Helical: 313-333
Extracellular: 334-396
Helical: 397-417
Cytoplasmic: 418-439
Helical: 440-460
Extracellular: 461-483
Helical: 484-504
Cytoplasmic: 505-532
Helical: 533-553
Extracellular: 554-584
Helical: 585-605
Cytoplasmic: 606-694

PTM

Ubiquitinated by ZNRF3, leading to its degradation by the proteasome.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Rabbit Anti-FZD8 Recombinant Antibody (CBXF-1242)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Rat Anti-FZD8 Recombinant Antibody (CBXF-1687) (CAT#: CBMAB-F4163-CQ)

Rabbit Anti-FZD8 Recombinant Antibody (EG1259) (CAT#: CBMAB-EN1522-LY)

Rat Anti-FZD8 (Extracellular domain) Recombinant Antibody (CBXF-0996) (CAT#: CBMAB-F0480-CQ)

Rat Anti-FZD8 Recombinant Antibody (CBXF-2191) (CAT#: CBMAB-F0709-CQ)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry