GIT2
This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding.
Full Name
GIT ArfGAP 2
Function
GTPase-activating protein for ADP ribosylation factor family members, including ARF1.
Biological Process
Regulation of G protein-coupled receptor signaling pathway Source: ProtInc
Cellular Location
Nucleoplasm; Focal adhesion
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Anti-GIT2 antibodies
+ Filters

Target: GIT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D8N9A
Application*: WB
Target: GIT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D6L1J
Application*: WB
Target: GIT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: D11B8
Application*: WB
Target: GIT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-1184
Application*: E, WB
Target: GIT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-1182
Application*: E, IF, P, WB
Target: GIT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-1180
Application*: WB
Target: GIT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: M1
Application*: E, IC, IF, IP, WB
Target: GIT2
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-3173
Application*: WB
Target: GIT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBLG1-102
Application*: E, IC, IH, WB
Target: GIT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3B5-B9
Application*: E, IF, IH, WB
Target: GIT2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1316
Application*: WB: 1:500~1:1000 ELISA: 1:10000
Target: GIT2
Specificity: Human
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot

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