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GJA4

This gene encodes a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene have been associated with atherosclerosis and a higher risk of myocardial infarction.

Full Name

gap junction protein alpha 4

Function

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

Biological Process

Blood vessel development Source: Ensembl
Calcium ion transport Source: Ensembl
Cell-cell junction assembly Source: ProtInc
Cell-cell signaling Source: GO_Central
Endothelium development Source: Ensembl
Response to pain Source: Ensembl

Cellular Location

Cell membrane; Gap junction

Topology

Cytoplasmic: 1-20
Helical: 21-40
Extracellular: 41-76
Helical: 77-99
Cytoplasmic: 100-148
Helical: 149-165
Extracellular: 166-207
Helical: 208-230
Cytoplasmic: 231-333

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Anti-GJA4 antibodies

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Mouse Anti-GJA4 Recombinant Antibody (CBLG1-1194) (CBMAB-G3552-LY)

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Target: GJA4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-1194

Application*: WB

Rabbit Anti-GJA4 Recombinant Antibody (EG1319) (CBMAB-EN1595-LY)

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Target: GJA4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat

Clone: EG1319

Application*: WB: 1:500~1:1000 ELISA: 1:40000

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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