GPR27

GPR27 is a member of the G protein-coupled receptors (GPCRs), a large family of receptors that have a similar structure characterized by 7 transmembrane domains. Activation of GPCRs by extracellular stimuli such as neurotransmitters, hormones, or light induces an intracellular signaling cascade mediated by heterotrimeric GTP-binding proteins, or G proteins.

Full Name

G Protein-Coupled Receptor 27

Function

Orphan receptor. Possible candidate for amine-like G-protein coupled receptor.

Biological Process

Positive regulation of insulin secretion involved in cellular response to glucose stimulus Source: Ensembl
Positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Cell membrane

Topology

Extracellular: 1-23
Helical: 24-44
Cytoplasmic: 45-55
Helical: 56-76
Extracellular: 77-97
Helical: 98-118
Cytoplasmic: 119-139
Helical: 140-160
Extracellular: 161-181
Helical: 182-202
Cytoplasmic: 203-285
Helical: 286-306
Extracellular: 307-320
Helical: 321-341
Cytoplasmic: 342-375