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GTF2H4

Ubiquitous expression in appendix (RPKM 9.1), endometrium (RPKM 8.7) and 25 other tissues.

Full Name

general transcription factor IIH, polypeptide 4, 52kDa

Function

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.

Biological Process

DNA repair Source: ProtInc
Nucleotide-excision repair Source: GO_Central
Phosphorylation of RNA polymerase II C-terminal domain Source: GO_Central
Transcription by RNA polymerase II Source: UniProtKB

Cellular Location

Nucleus

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Anti-GTF2H4 antibodies

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Mouse Anti-GTF2H4 Recombinant Antibody (CBYJT-1329) (CBMAB-T0345-YJ)

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Target: GTF2H4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat, Mouse

Clone: CBYJT-1329

Application*: WB, IP, IF, P, E

Mouse Anti-GTF2H4 Recombinant Antibody (CBYJT-1328) (CBMAB-T0344-YJ)

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Target: GTF2H4

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBYJT-1328

Application*: WB, IP, IF, E

Mouse Anti-GTF2H4 Recombinant Antibody (CBYJT-1327) (CBMAB-T0343-YJ)

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Target: GTF2H4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBYJT-1327

Application*: E, WB, IC, IP

Mouse Anti-GTF2H4 Recombinant Antibody (CBLG1-2123) (CBMAB-G5718-LY)

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Target: GTF2H4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBLG1-2123

Application*: WB

Mouse Anti-GTF2H4 Recombinant Antibody (4F6) (CBMAB-G5715-LY)

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Target: GTF2H4

Host: Mouse

Antibody Isotype: IgG2b, κ

Specificity: Human

Clone: 4F6

Application*: E, WB

Mouse Anti-GTF2H4 Recombinant Antibody (362C2a) (CBMAB-G0923-LY)

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Target: GTF2H4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: 362C2a

Application*: DB, WB

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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