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GZMC

This gene encodes a member of the peptidase S1 family of serine proteases. The encoded preproprotein is proteolytically processed to generate a mature protein product. This product, expressed by activated T cells, may induce apoptosis of target cells. This gene is present in a gene cluster with other members of the granzyme subfamily on chromosome 14.

Full Name

granzyme C

Function

This enzyme is probably necessary for target cell lysis in cell-mediated immune responses.

Biological Process

Cytolysis Source: UniProtKB-KW
Granzyme-mediated programmed cell death signaling pathway Source: MGI
Natural killer cell mediated cytotoxicity Source: MGI
Negative regulation of translation Source: MGI
Proteolysis involved in cellular protein catabolic process Source: MGI

Cellular Location

Cytolytic granule

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Anti-GZMC antibodies

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Hamster Anti-GZMC Recombinant Antibody (G1013) (V2LY-0226-LY2301)

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Target: GZMC

Host: Hamster

Antibody Isotype: IgG

Specificity: Mouse

Clone: G1013

Application*: F

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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