GZMH

This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14.
Full Name
granzyme H
Function
Cytotoxic chymotrypsin-like serine protease with preference for bulky and aromatic residues at the P1 position and acidic residues at the P3' and P4' sites. Probably necessary for target cell lysis in cell-mediated immune responses. Participates in the antiviral response via direct cleavage of several proteins essential for viral replication.
Biological Process
Apoptotic process Source: UniProtKB
Cytolysis Source: UniProtKB-KW
Cellular Location
Cytolytic granule
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Anti-GZMH antibodies

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Rabbit Anti-GZMH Recombinant Antibody (EG1426) (CBMAB-EN1705-LY)

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Target: GZMH
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1426
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:5000
Datasheet SDS

Mouse Anti-GZMH Recombinant Antibody (CBFYH-3495) (CBMAB-H4045-FY)

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Target: GZMH
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBFYH-3495
Application*: WB
Datasheet SDS

Mouse Anti-GZMH Recombinant Antibody (3G10F4) (CBMAB-G5961-LY)

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Target: GZMH
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: 3G10F4
Application*: E
Datasheet SDS

Mouse Anti-GZMH Recombinant Antibody (10A39) (CBMAB-G5960-LY)

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Target: GZMH
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: 10A39
Application*: WB
Datasheet SDS

Mouse Anti-GZMH Recombinant Antibody (185813) (CBMAB-G1016-LY)

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Target: GZMH
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 185813
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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