HDAC10

The protein encoded by this gene belongs to the histone deacetylase family, members of which deacetylate lysine residues on the N-terminal part of the core histones. Histone deacetylation modulates chromatin structure, and plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Full Name
HDAC10
Function
Polyamine deacetylase (PDAC), which acts preferentially on N8-acetylspermidine, and also on acetylcadaverine and acetylputrescine (PubMed:28516954).

Exhibits attenuated catalytic activity toward N1,N8-diacetylspermidine and very low activity, if any, toward N1-acetylspermidine (PubMed:28516954).

Histone deacetylase activity has been observed in vitro (PubMed:11861901, PubMed:11726666, PubMed:11677242, PubMed:11739383).

Has also been shown to be involved in MSH2 deacetylation (PubMed:26221039).

The physiological relevance of protein/histone deacetylase activity is unclear and could be very weak (PubMed:28516954).

May play a role in the promotion of late stages of autophagy, possibly autophagosome-lysosome fusion and/or lysosomal exocytosis in neuroblastoma cells (PubMed:23801752, PubMed:29968769).

May play a role in homologous recombination (PubMed:21247901).

May promote DNA mismatch repair (PubMed:26221039).
Biological Process
Chromatin organization Source: UniProtKB
DNA repair Source: UniProtKB-KW
Histone deacetylation Source: UniProtKB
Homologous recombination Source: UniProtKB
Macroautophagy Source: UniProtKB
Negative regulation of transcription, DNA-templated Source: UniProtKB
Negative regulation of transcription by RNA polymerase II Source: UniProtKB
Peptidyl-lysine deacetylation Source: UniProtKB
Polyamine deacetylation Source: UniProtKB
Positive regulation of mismatch repair Source: UniProtKB
Protein deacetylation Source: UniProtKB
Regulation of transcription, DNA-templated Source: UniProtKB
Spermidine deacetylation Source: UniProtKB
Cellular Location
Cytoplasm; Nucleus. Excluded from nucleoli.
Involvement in disease
In neuroblastoma cells, may promote autophagy in response to chemotherapy-induced DNA damage and efflux of chemotherapeutics via lysosomal exocytosis, hence protecting cells from cytotoxic agents (PubMed:23801752, PubMed:29968769). Expression levels may correlate with survival in neuroblastoma patients, with low levels in the tumor correlating with long-term patient survival and high expression with poor prognosis (PubMed:23801752). Therefore has been proposed as a biomarker to predict neuroblastoma chemoresistance and treatment outcome (PubMed:23801752).
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Anti-HDAC10 antibodies

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Mouse Anti-HDAC10 Antibody (1B2) (CBMAB-0440-YC)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1B2
Application*: E, IP
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBT3409) (V2LY-0625-LY171)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBT3409
Application*: IH
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0826) (CBMAB-H1738-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0826
Application*: F, IH, IP, WB
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0824) (CBMAB-H1736-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0824
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0823) (CBMAB-H1735-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0823
Application*: WB, IH, F
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0822) (CBMAB-H1734-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0822
Application*: WB, IP
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0821) (CBMAB-H1733-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0821
Application*: WB, F, IP
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0820) (CBMAB-H1732-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-0820
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0819) (CBMAB-H1731-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0819
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0818) (CBMAB-H1730-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0818
Application*: IF, P, WB
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0817) (CBMAB-H1729-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0817
Application*: IH, WB
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (CBFYH-0816) (CBMAB-H1728-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0816
Application*: F, P, WB
Datasheet SDS

Mouse Anti-HDAC10 Recombinant Antibody (3B6B8) (CBMAB-H1727-FY)

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Target: HDAC10
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 3B6B8
Application*: E, WB, P, IF, F
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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