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HIF1AN

HIF1AN (Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor) is a Protein Coding gene. Diseases associated with HIF1AN include Hypoxia and Anemia Of Prematurity. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and HIF-2-alpha transcription factor network. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. An important paralog of this gene is HSPBAP1.
Full Name
Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor
Function
Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.
Biological Process
Negative regulation of Notch signaling pathway Source: UniProtKB
Negative regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
Peptidyl-asparagine hydroxylation Source: UniProtKB
Peptidyl-aspartic acid hydroxylation Source: UniProtKB
Peptidyl-histidine hydroxylation Source: UniProtKB
Positive regulation of myoblast differentiation Source: UniProtKB
Positive regulation of vasculogenesis Source: UniProtKB
Cellular Location
Nucleus; Cytoplasm; Perinuclear region. Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.
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Anti-HIF1AN antibodies

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Mouse Anti-HIF1AN Recombinant Antibody (162c) (CBMAB-AP2285LY)

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Target: HIF1AN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: 162c
Application*: ICC/IF, IHC, WB
Datasheet SDS

Mouse Anti-HIF1AN Recombinant Antibody (1D8) (CBMAB-A3899-LY)

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Target: HIF1AN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1D8
Application*: WB, E
Datasheet SDS

Mouse Anti-HIF1AN Recombinant Antibody (CBXF-2696) (CBMAB-F3098-CQ)

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Target: HIF1AN
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBXF-2696
Application*: WB
Datasheet SDS

Rabbit Anti-HIF1AN Recombinant Antibody (CBXF-2089) (CBMAB-F2029-CQ)

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Target: HIF1AN
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey
Clone: CBXF-2089
Application*: WB
Datasheet SDS

Mouse Anti-HIF1AN Recombinant Antibody (FIH 162c) (CBMAB-F0207-CQ)

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Target: HIF1AN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: FIH 162c
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-HIF1AN Recombinant Antibody (CBXF-2473) (CBMAB-F0088-CQ)

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Target: HIF1AN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBXF-2473
Application*: WB, IH, IF, P
Datasheet SDS

Mouse Anti-HIF1AN (AA 1-349) Recombinant Antibody (CBFYH-1099) (CBMAB-H2050-FY)

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Target: HIF1AN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1099
Application*: E, IF, IP, WB
Datasheet SDS

Mouse Anti-HIF1AN Recombinant Antibody (FIH162C) (CBMAB-H2048-FY)

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Target: HIF1AN
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: FIH162C
Application*: P, WB
Datasheet SDS

Mouse Anti-HIF1AN Recombinant Antibody (CBFYH-1098) (CBMAB-H0681-FY)

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Target: HIF1AN
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1098
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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