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HIF1AN

HIF1AN (Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor) is a Protein Coding gene. Diseases associated with HIF1AN include Hypoxia and Anemia Of Prematurity. Among its related pathways are CDK-mediated phosphorylation and removal of Cdc6 and HIF-2-alpha transcription factor network. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity and oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors. An important paralog of this gene is HSPBAP1.

Full Name

Hypoxia Inducible Factor 1 Alpha Subunit Inhibitor

Function

Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation.

Biological Process

Negative regulation of Notch signaling pathway Source: UniProtKB
Negative regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: UniProtKB
Peptidyl-asparagine hydroxylation Source: UniProtKB
Peptidyl-aspartic acid hydroxylation Source: UniProtKB
Peptidyl-histidine hydroxylation Source: UniProtKB
Positive regulation of myoblast differentiation Source: UniProtKB
Positive regulation of vasculogenesis Source: UniProtKB

Cellular Location

Nucleus; Cytoplasm; Perinuclear region. Mainly cytoplasmic localization, but interaction with NOTCH1 results in nuclear localization and interaction with ABPA3 results in perinuclear localization in macrophages.

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Anti-HIF1AN antibodies

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Human HIF1AN ELISA Kit (V2LY-0626-LY3619)

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Target: HIF1AN

Sensitivity: 0.0051 ng/mL

Detection Range: 0.01-2 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Rabbit Anti-HIF1AN Recombinant Antibody (
12F11) (V2LY-0725-LY1121)

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Target: HIF1AN

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 12F11

Application*: E, WB, IH, IF, F

Mouse Anti-HIF1AN Recombinant Antibody (162c) (CBMAB-AP2285LY)

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Target: HIF1AN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: 162c

Application*: ICC/IF, IHC, WB

Mouse Anti-HIF1AN Recombinant Antibody (1D8) (CBMAB-A3899-LY)

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Target: HIF1AN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1D8

Application*: WB, E

Mouse Anti-HIF1AN Recombinant Antibody (CBXF-2696) (CBMAB-F3098-CQ)

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Target: HIF1AN

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human, Mouse

Clone: CBXF-2696

Application*: WB

Rabbit Anti-HIF1AN Recombinant Antibody (CBXF-2089) (CBMAB-F2029-CQ)

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Target: HIF1AN

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human, Mouse, Rat, Monkey

Clone: CBXF-2089

Application*: WB

Mouse Anti-HIF1AN Recombinant Antibody (FIH 162c) (CBMAB-F0207-CQ)

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Target: HIF1AN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Mouse

Clone: FIH 162c

Application*: WB, IH, IF

Mouse Anti-HIF1AN Recombinant Antibody (CBXF-2473) (CBMAB-F0088-CQ)

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Target: HIF1AN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBXF-2473

Application*: WB, IH, IF, P

Mouse Anti-HIF1AN (AA 1-349) Recombinant Antibody (CBFYH-1099) (CBMAB-H2050-FY)

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Target: HIF1AN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-1099

Application*: E, IF, IP, WB

Mouse Anti-HIF1AN Recombinant Antibody (FIH162C) (CBMAB-H2048-FY)

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Target: HIF1AN

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: FIH162C

Application*: P, WB

Mouse Anti-HIF1AN Recombinant Antibody (CBFYH-1098) (CBMAB-H0681-FY)

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Target: HIF1AN

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-1098

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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