HNMT
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq]
Full Name
histamine N-methyltransferase
Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Biological Process
Histamine catabolic process Source: UniProtKB
Histamine metabolic process Source: ARUK-UCL
Histidine catabolic process Source: Reactome
Methylation Source: UniProtKB
Respiratory gaseous exchange by respiratory system Source: ProtInc
Histamine metabolic process Source: ARUK-UCL
Histidine catabolic process Source: Reactome
Methylation Source: UniProtKB
Respiratory gaseous exchange by respiratory system Source: ProtInc
Cellular Location
Cytoplasm
Involvement in disease
Mental retardation, autosomal recessive 51 (MRT51):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
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Anti-HNMT antibodies
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Target: HNMT
Expressed Host: E. coli
Sequence: Amino Acid: 1-292
Tag: GST Tag
Target: HNMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1617
Application*: WB
Target: HNMT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-1615
Application*: E, WB
Target: HNMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-1613
Application*: E, WB, IP
Target: HNMT
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYH-1612
Application*: E, WB
Target: HNMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3178
Application*: E, WB
Target: HNMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0353
Application*: WB
Target: HNMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0352
Application*: WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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