HNMT

In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq]
Full Name
histamine N-methyltransferase
Function
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.
Biological Process
Histamine catabolic process Source: UniProtKB
Histamine metabolic process Source: ARUK-UCL
Histidine catabolic process Source: Reactome
Methylation Source: UniProtKB
Respiratory gaseous exchange by respiratory system Source: ProtInc
Cellular Location
Cytoplasm
Involvement in disease
Mental retardation, autosomal recessive 51 (MRT51):
A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period.
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Anti-HNMT antibodies

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Target: HNMT
Expressed Host: E. coli
Sequence: Amino Acid: 1-292
Tag: GST Tag
Target: HNMT
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-1617
Application*: WB
Target: HNMT
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-1615
Application*: E, WB
Target: HNMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-1613
Application*: E, WB, IP
Target: HNMT
Host: Mouse
Antibody Isotype: IgG3, κ
Specificity: Human
Clone: CBFYH-1612
Application*: E, WB
Target: HNMT
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3178
Application*: E, WB
Target: HNMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: BA0353
Application*: WB
Target: HNMT
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: BA0352
Application*: WB
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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