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HTR5A

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]

Full Name

5-Hydroxytryptamine Receptor 5A

Function

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Hippocampus development Source: Ensembl
Response to estradiol Source: Ensembl

Cellular Location

Cell membrane

Topology

Extracellular: 1-40
Helical: 41-63
Cytoplasmic: 64-78
Helical: 79-99
Extracellular: 100-115
Helical: 116-137
Cytoplasmic: 138-158
Helical: 159-181
Extracellular: 182-198
Helical: 199-219
Cytoplasmic: 220-282
Helical: 283-303
Extracellular: 304-320
Helical: 321-341
Cytoplasmic: 342-357

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Anti-HTR5A antibodies

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Rabbit Anti-HTR5A Recombinant Antibody (EG1593) (CBMAB-EN1906-LY)

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Target: HTR5A

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: EG1593

Application*: WB: 1:500~1:1000 ELISA: 1:20000

Mouse Anti-HTR5A Recombinant Antibody (3D1) (CBMAB-A4156-LY)

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Target: HTR5A

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human, Rat

Clone: 3D1

Application*: WB, E

Mouse Anti-HTR5A Recombinant Antibody (10D3) (CBMAB-A4155-LY)

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Target: HTR5A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 10D3

Application*: WB, E

Mouse Anti-HTR5A (AA 223-282) Recombinant Antibody (CBFYH-2505) (CBMAB-H3519-FY)

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Target: HTR5A

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: CBFYH-2505

Application*: E, WB

Mouse Anti-HTR5A (AA 223-283) Recombinant Antibody (CBFYH-2504) (CBMAB-H3518-FY)

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Target: HTR5A

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: CBFYH-2504

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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