HTR5A

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008]

5-Hydroxytryptamine Receptor 5A

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Hippocampus development Source: Ensembl
Response to estradiol Source: Ensembl

Cell membrane

Extracellular: 1-40
Helical: 41-63
Cytoplasmic: 64-78
Helical: 79-99
Extracellular: 100-115
Helical: 116-137
Cytoplasmic: 138-158
Helical: 159-181
Extracellular: 182-198
Helical: 199-219
Cytoplasmic: 220-282
Helical: 283-303
Extracellular: 304-320
Helical: 321-341
Cytoplasmic: 342-357