IL11

The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Full Name
Interleukin 11
Function
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578).

Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066).

Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168).
Biological Process
B cell differentiation Source: UniProtKB
Fat cell differentiation Source: UniProtKB
Megakaryocyte differentiation Source: UniProtKB
Negative regulation of hormone secretion Source: MGI
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: MGI
Positive regulation of peptidyl-serine phosphorylation Source: MGI
Positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Cellular Location
Secreted
Involvement in disease
Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.
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Anti-IL11 antibodies

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Mouse Anti-IL11 Recombinant Antibody (3C6) (CBMAB-A4323-LY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 3C6
Application*: WB, E
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (CBYC-A982) (CBMAB-A4479-YC)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYC-A982
Application*: WB, IC, P, C, E
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (CBT765) (V2LY-0625-LY3295)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT765
Application*: WB, E
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (CBT4822) (V2LY-0625-LY2089)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT4822
Application*: WB
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (A459) (CBMAB-AP3782LY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A459
Application*: Sandwich ELISA, WB, IHC
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (KT8) (CBMAB-AO609LY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: KT8
Application*: ELISA
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (1F1) (CBMAB-A4322-LY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1F1
Application*: E, E
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (CBYY-I1456) (CBMAB-I2626-YY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1456
Application*: N, WB
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (CBYY-I1263) (CBMAB-I2432-YY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1263
Application*: E, N
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (CBYY-I0824) (CBMAB-I1854-YY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBYY-I0824
Application*: N
Datasheet SDS

Mouse Anti-IL11 Recombinant Antibody (6D9A1) (CBMAB-I1573-YY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D9A1
Application*: WB, E, IH
Datasheet SDS

Mouse Anti-IL11 (AA 1-423) Recombinant Antibody (22616) (CBMAB-I0368-YY)

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Target: IL11
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 22616
Application*: WB, E
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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