Mouse Anti-IL11 Recombinant Antibody (CBT4822) (V2LY-0625-LY2089)

Name: Mouse Anti-IL11 Recombinant Antibody (CBT4822)
SKU: V2LY-0625-LY2089
Rating: 5 (1 reviews)

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Tested Data

Mouse Anti-IL11 Recombinant Antibody (CBT4822) (V2LY-0625-LY2089) in WB

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBT4822

Application

Immunogen

Purified recombinant fragment of human IL-11 expressed in E. Coli.

Host Species

Mouse

Specificity

Human

Antibody Isotype

IgG1

Clonality

Monoclonal Antibody

Application Notes

Application	Note
WB	1:500-1:2,000
ELISA	1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS

Preservative

Sodium azide

Concentration

Batch dependent

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Interleukin 11

Entrez Gene ID

3589

UniProt ID

P20809

Function

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578).

Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066).

Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168).

Biological Process

B cell differentiation Source: UniProtKB
Fat cell differentiation Source: UniProtKB
Megakaryocyte differentiation Source: UniProtKB
Negative regulation of hormone secretion Source: MGI
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: MGI
Positive regulation of peptidyl-serine phosphorylation Source: MGI
Positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI

Cellular Location

Secreted

Involvement in disease

Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Bai, X., Zhao, G., Chen, Q., Li, Z., Gao, M., Ho, W., ... & Zhang, X. Q. (2022). Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. Science Advances, 8(25), eabn7162.

Lim, W. W., Dong, J., Ng, B., Widjaja, A. A., Xie, C., Su, L., ... & Cook, S. A. (2022). Inhibition of IL11 signaling reduces aortic pathology in murine marfan syndrome. Circulation Research, 130(5), 728-740.

Widjaja, A. A., Chothani, S., Viswanathan, S., Goh, J. W. T., Lim, W. W., & Cook, S. A. (2022). IL11 stimulates IL33 expression and proinflammatory fibroblast activation across tissues. International Journal of Molecular Sciences, 23(16), 8900.

Widjaja, A. A., Viswanathan, S., Ting, J. G. W., Tan, J., Shekeran, S. G., Carling, D., ... & Cook, S. A. (2022). IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells. Iscience, 25(8).

Dong, J., Viswanathan, S., Adami, E., Singh, B. K., Chothani, S. P., Ng, B., ... & Widjaja, A. A. (2021). Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nature communications, 12(1), 66.

Widjaja, A. A., Dong, J., Adami, E., Viswanathan, S., Ng, B., Pakkiri, L. S., ... & Cook, S. A. (2021). Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Science Translational Medicine, 13(597), eaba8146.

Moon, E. J., Mello, S. S., Li, C. G., Chi, J. T., Thakkar, K., Kirkland, J. G., ... & Giaccia, A. J. (2021). The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. Nature communications, 12(1), 4308.

Widjaja, A. A., Viswanathan, S., Jinrui, D., Singh, B. K., Tan, J., Wei Ting, J. G., ... & Cook, S. A. (2021). Molecular dissection of pro-fibrotic IL11 signaling in cardiac and pulmonary fibroblasts. Frontiers in Molecular Biosciences, 8, 740650.

Adami, E., Viswanathan, S., Widjaja, A. A., Ng, B., Chothani, S., Zhihao, N., ... & Cook, S. A. (2021). IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts. Rheumatology, 60(12), 5820-5826.

Styrkarsdottir, U., Lund, S. H., Thorleifsson, G., Zink, F., Stefansson, O. A., Sigurdsson, J. K., ... & Stefansson, K. (2018). Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. Nature genetics, 50(12), 1681-1687.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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