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Mouse Anti-IL11 Recombinant Antibody (CBYY-I0824) (CBMAB-I1854-YY)

This product is Mouse antibody that recognizes IL11. The antibody CBYY-I0824 can be used for immunoassay techniques such as: Neut
See all IL11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0824
Antibody Isotype
IgG2a, κ
Application
Neut

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Concentration
1.0 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 11
Introduction
The protein encoded by this gene is a member of the gp130 family of cytokines. These cytokines drive the assembly of multisubunit receptor complexes, all of which contain at least one molecule of the transmembrane signaling receptor IL6ST (gp130). This cytokine is shown to stimulate the T-cell-dependent development of immunoglobulin-producing B cells. It is also found to support the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Entrez Gene ID
3589
UniProt ID
P20809
Alternative Names
Interleukin 11
Function
Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:2145578).

Also promotes the proliferation of hepatocytes in response to liver damage. Binding to its receptor formed by IL6ST and IL11RA activates a signaling cascade that promotes cell proliferation (PubMed:12919066).

Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3. The interaction with the membrane-bound IL11RA and IL6ST stimulates 'classic signaling', whereas the binding of IL11 and soluble IL11RA to IL6ST stimulates 'trans-signaling' (PubMed:30279168).
Biological Process
B cell differentiation Source: UniProtKB
Fat cell differentiation Source: UniProtKB
Megakaryocyte differentiation Source: UniProtKB
Negative regulation of hormone secretion Source: MGI
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of MAPK cascade Source: MGI
Positive regulation of peptidyl-serine phosphorylation Source: MGI
Positive regulation of peptidyl-tyrosine phosphorylation Source: MGI
Positive regulation of transcription by RNA polymerase II Source: MGI
Cellular Location
Secreted
Involvement in disease
Available under the name Neumega (Wyeth). Used for the prevention of severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.

Bai, X., Zhao, G., Chen, Q., Li, Z., Gao, M., Ho, W., ... & Zhang, X. Q. (2022). Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. Science Advances, 8(25), eabn7162.

Lim, W. W., Dong, J., Ng, B., Widjaja, A. A., Xie, C., Su, L., ... & Cook, S. A. (2022). Inhibition of IL11 signaling reduces aortic pathology in murine marfan syndrome. Circulation Research, 130(5), 728-740.

Widjaja, A. A., Chothani, S., Viswanathan, S., Goh, J. W. T., Lim, W. W., & Cook, S. A. (2022). IL11 stimulates IL33 expression and proinflammatory fibroblast activation across tissues. International Journal of Molecular Sciences, 23(16), 8900.

Widjaja, A. A., Viswanathan, S., Ting, J. G. W., Tan, J., Shekeran, S. G., Carling, D., ... & Cook, S. A. (2022). IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells. Iscience, 25(8).

Dong, J., Viswanathan, S., Adami, E., Singh, B. K., Chothani, S. P., Ng, B., ... & Widjaja, A. A. (2021). Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH. Nature communications, 12(1), 66.

Widjaja, A. A., Dong, J., Adami, E., Viswanathan, S., Ng, B., Pakkiri, L. S., ... & Cook, S. A. (2021). Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Science Translational Medicine, 13(597), eaba8146.

Moon, E. J., Mello, S. S., Li, C. G., Chi, J. T., Thakkar, K., Kirkland, J. G., ... & Giaccia, A. J. (2021). The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. Nature communications, 12(1), 4308.

Widjaja, A. A., Viswanathan, S., Jinrui, D., Singh, B. K., Tan, J., Wei Ting, J. G., ... & Cook, S. A. (2021). Molecular dissection of pro-fibrotic IL11 signaling in cardiac and pulmonary fibroblasts. Frontiers in Molecular Biosciences, 8, 740650.

Adami, E., Viswanathan, S., Widjaja, A. A., Ng, B., Chothani, S., Zhihao, N., ... & Cook, S. A. (2021). IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts. Rheumatology, 60(12), 5820-5826.

Styrkarsdottir, U., Lund, S. H., Thorleifsson, G., Zink, F., Stefansson, O. A., Sigurdsson, J. K., ... & Stefansson, K. (2018). Meta-analysis of Icelandic and UK data sets identifies missense variants in SMO, IL11, COL11A1 and 13 more new loci associated with osteoarthritis. Nature genetics, 50(12), 1681-1687.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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