IL4

The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Interleukin 4

Participates in at least several B-cell activation processes as well as of other cell types (PubMed:3016727).
It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (By similarity).
Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4 (By similarity).

Activation of Janus kinase activityManual Assertion Based On ExperimentIGI:ARUK-UCL
B cell costimulationManual Assertion Based On ExperimentIBA:GO_Central
B cell differentiationManual Assertion Based On ExperimentTAS:UniProtKB
Cholesterol metabolic processBy SimilarityISS:UniProtKB
Dendritic cell differentiationManual Assertion Based On ExperimentIDA:DFLAT
Extrinsic apoptotic signaling pathway in absence of ligandManual Assertion Based On ExperimentIBA:GO_Central
Immune responseManual Assertion Based On ExperimentTAS:ProtInc
Innate immune response in mucosaManual Assertion Based On ExperimentIBA:GO_Central
Macrophage activationManual Assertion Based On ExperimentIGI:ARUK-UCL
Microglial cell activationManual Assertion Based On ExperimentIBA:GO_Central
Myeloid dendritic cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of acute inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processISS:UniProtKB
Negative regulation of cellular response to transforming growth factor beta stimulusManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of chronic inflammatory responseManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of complement-dependent cytotoxicityManual Assertion Based On ExperimentIMP:AgBase
Negative regulation of endothelial cell apoptotic processManual Assertion Based On ExperimentIMP:AgBase
Negative regulation of epithelial cell migrationManual Assertion Based On ExperimentIDA:CACAO
Negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of inflammatory responseManual Assertion Based On ExperimentIGI:ARUK-UCL
Negative regulation of macrophage activationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of neuroinflammatory responseIC:ARUK-UCL
Negative regulation of osteoclast differentiationISS:UniProtKB
Negative regulation of T-helper 17 cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of tumor necrosis factor productionISS:ARUK-UCL
Neuroinflammatory responseISS:ARUK-UCL
Positive regulation of amyloid-beta clearanceISS:ARUK-UCL
Positive regulation of ATP biosynthetic processISS:ARUK-UCL
Positive regulation of B cell proliferationISS:UniProtKB
Positive regulation of cell migrationManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of cell population proliferationManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of cellular respirationISS:ARUK-UCL
Positive regulation of cold-induced thermogenesisBy SimilarityISS:YuBioLab
Positive regulation of defense response to virus by hostManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of eosinophil chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of gene expressionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of interleukin-10 productionManual Assertion Based On ExperimentIGI:ARUK-UCL
Positive regulation of interleukin-13 productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of isotype switching to IgE isotypesISS:UniProtKB
Positive regulation of isotype switching to IgG isotypesISS:UniProtKB
Positive regulation of macroautophagyISS:UniProtKB
Positive regulation of mast cell degranulationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of MHC class II biosynthetic processISS:UniProtKB
Positive regulation of mononuclear cell migrationManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of myoblast fusionManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of receptor-mediated endocytosisISS:ARUK-UCL
Positive regulation of T cell differentiationManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of T cell proliferationISS:UniProtKB
Positive regulation of T-helper 2 cell cytokine productionManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of transcription by RNA polymerase IIISS:UniProtKB
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of tyrosine phosphorylation of STAT proteinManual Assertion Based On ExperimentIGI:ARUK-UCL
Regulation of immune responseISS:UniProtKB
Regulation of isotype switchingManual Assertion Based On ExperimentTAS:UniProtKB
Regulation of phosphorylationISS:UniProtKB
T cell activationManual Assertion Based On ExperimentIGI:BHF-UCL
T-helper 2 cell differentiationManual Assertion Based On ExperimentIBA:GO_Central
Type 2 immune responseManual Assertion Based On ExperimentTAS:UniProtKB

Secreted

Ischemic stroke (ISCHSTR):
A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors.