IST1

This gene encodes a protein with MIT-interacting motifs that interacts with components of endosomal sorting complexes required for transport (ESCRT). ESCRT functions in vesicle budding, such as that which occurs during membrane abscission in cytokinesis. There is a pseudogene for this gene on chromosome 19. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Full Name

IST1, ESCRT-III Associated Factor

Function

ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692).
Is required for efficient abscission during cytokinesis (PubMed:19129479).
Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129480, PubMed:19129479).
During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712).
Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692).
Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).

Biological Process

AbscissionManual Assertion Based On ExperimentIDA:UniProtKB
Cell divisionManual Assertion Based On ExperimentIMP:UniProtKB
Cytoskeleton-dependent cytokinesisManual Assertion Based On ExperimentIMP:UniProtKB
ESCRT III complex disassembly1 PublicationNAS:ParkinsonsUK-UCL
Establishment of protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Multivesicular body assembly1 PublicationNAS:ParkinsonsUK-UCL
Positive regulation of collateral sproutingIEA:Ensembl
Positive regulation of proteolysisManual Assertion Based On ExperimentIDA:UniProtKB
Protein localizationManual Assertion Based On ExperimentIMP:UniProtKB
Protein transportIEA:InterPro
Viral capsid secondary envelopmentManual Assertion Based On ExperimentIDA:UniProtKB
Viral release from host cellManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cytoplasmic vesicle; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Midbody; Nucleus envelope. Localizes to centrosome and midbody of dividing cells (PubMed:19129480, PubMed:19129479, PubMed:20719964).
Colocalized with SPART to the ends of Flemming bodies during cytokinesis (PubMed:20719964).
Localizes to the reforming nuclear envelope on chromatin disks during late anaphase