KCNC3

The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. [provided by RefSeq]

potassium voltage-gated channel, Shaw-related subfamily, member 3

Voltage-gated potassium channel that plays an important role in the rapid repolarization of fast-firing brain neurons. The channel opens in response to the voltage difference across the membrane, forming a potassium-selective channel through which potassium ions pass in accordance with their electrochemical gradient. The channel displays rapid activation and inactivation kinetics (PubMed:10712820, PubMed:26997484, PubMed:22289912, PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792).
It plays a role in the regulation of the frequency, shape and duration of action potentials in Purkinje cells. Required for normal survival of cerebellar neurons, probably via its role in regulating the duration and frequency of action potentials that in turn regulate the activity of voltage-gated Ca(2+) channels and cellular Ca(2+) homeostasis (By similarity).
Required for normal motor function (PubMed:23734863, PubMed:16501573, PubMed:19953606, PubMed:21479265, PubMed:25756792).
Plays a role in the reorganization of the cortical actin cytoskeleton and the formation of actin veil structures in neuronal growth cones via its interaction with HAX1 and the Arp2/3 complex (PubMed:26997484).

Potassium ion transmembrane transportManual Assertion Based On ExperimentIMP:UniProtKB
Protein homooligomerizationIEA:InterPro
Protein tetramerizationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of ion transmembrane transportIEA:UniProtKB-KW

Cell membrane; Cell junction, synapse, presynaptic cell membrane; Perikaryon; Cell projection, axon; Cell projection, dendrite; Cell projection, dendritic spine membrane; Cytoplasm, cell cortex; Cytoplasm, cytoskeleton. Detected on Purkinje cell dendritic spines, positioned perisynaptically but also in extrasynaptic positions along the spine membranes (By similarity).
Detected at presynaptic calices of Held (By similarity).
Colocalizes with the cortical actin cytoskeleton and the Arp2/3 complex (PubMed:26997484).

Spinocerebellar ataxia 13 (SCA13):
Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA13 is an autosomal dominant cerebellar ataxia (ADCA) characterized by slow progression and variable age at onset, ranging from childhood to late adulthood. Mental retardation can be present in some patients.

Cytoplasmic: 1-290
Helical: 291-309
Extracellular: 351-370
Helical: 371-379
Cytoplasmic: 380-398
Helical: 412-434
Extracellular: 435-447
Helical: 448-469
Helical: 518-539
Cytoplasmic: 540-757

N-glycosylated.