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KCNIP4

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Full Name

Potassium Voltage-Gated Channel Interacting Protein 4

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435).
Modulates KCND3/Kv4.3 currents (PubMed:23576435).
Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440).
Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.

Biological Process

Protein localization to plasma membraneISS:UniProtKB
Regulation of potassium ion transmembrane transportISS:UniProtKB

Cellular Location

Cell membrane; Cytoplasm
Isoform 4: Endoplasmic reticulum

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Anti-KCNIP4 antibodies

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Human KCNIP4 ELISA Kit (V2LY-0626-LY3958)

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Target: KCNIP4

Sensitivity: 0.024 ng/mL

Detection Range: 0.05-30 ng/mL

Sample Type: Serum, Plasma, cell culture supernates

Specificity: Human

Assay Type: Sandwich

Reactivity: Human

Mouse Anti-KCNIP4 Recombinant Antibody (A736) (CBMAB-AP10985LY)

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Target: KCNIP4

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human, Rat

Clone: A736

Application*: ELISA, IHC, WB

Rabbit Anti-KCNIP4 Recombinant Antibody (CBLY1-051) (CBMAB-K0559-LY)

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Target: KCNIP4

Host: Rabbit

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: CBLY1-051

Application*: WB, IP

Mouse Anti-KCNIP4 Recombinant Antibody (1A11) (CBMAB-1593-CN)

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Target: KCNIP4

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human

Clone: 1A11

Application*: WB, E, IF

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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