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Mouse Anti-KCNIP4 Recombinant Antibody (A736) (CBMAB-AP10985LY)

The product is antibody recognizes KCNIP4. The antibody A736 immunoassay techniques such as: ELISA, IHC, WB.
See all KCNIP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
A736
Antibody Isotype
IgG1
Application
ELISA, IHC, WB

Basic Information

Immunogen
Fusion protein of KCNIP4
Specificity
Human, Rat
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
Affinity purity
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Potassium Voltage-Gated Channel Interacting Protein 4
Introduction
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human80333
Rat259243
UniProt ID
HumanQ6PIL6
RatQ99MG9
Alternative Names
Potassium Voltage-Gated Channel Interacting Protein 4; A-Type Potassium Channel Modulatory Protein 4; Kv Channel Interacting Protein 4; Calsenilin-Like Protein; KCHIP4; CALP; Potassium Channel-Interacting Protein 4; Kv Channel-Interacting Protein 4;
Function
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435).
Modulates KCND3/Kv4.3 currents (PubMed:23576435).
Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440).
Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
Biological Process
Protein localization to plasma membraneISS:UniProtKB
Regulation of potassium ion transmembrane transportISS:UniProtKB
Cellular Location
Cell membrane; Cytoplasm
Isoform 4: Endoplasmic reticulum
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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