Human KCNIP4 ELISA Kit (V2LY-0626-LY3958)

Name: Human KCNIP4 ELISA Kit
SKU: V2LY-0626-LY3958
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.024 ng/mL

Detection Range

0.05-30 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

28.7 kDa

Components

Pre-coated ELISA plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Potassium Voltage-Gated Channel Interacting Protein 4

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435).
Modulates KCND3/Kv4.3 currents (PubMed:23576435).
Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440).
Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.

Biological Process

Protein localization to plasma membraneISS:UniProtKB
Regulation of potassium ion transmembrane transportISS:UniProtKB

Cellular Location

Cell membrane; Cytoplasm
Isoform 4: Endoplasmic reticulum

Jenkins, C. A., Kalmar, L., Matiasek, K., Mari, L., Kyöstilä, K., Lohi, H., ... & Ricketts, S. L. (2020). Characterisation of canine KCNIP4: A novel gene for cerebellar ataxia identified by whole-genome sequencing two affected Norwegian Buhund dogs. PLoS Genetics, 16(1), e1008527.

Su, Z. J., Wang, X. Y., Zhou, C., & Chai, Z. (2020). Down‐regulation of miR‐3068‐3p enhances kcnip4‐regulated A‐type potassium current to protect against glutamate‐induced excitotoxicity. Journal of Neurochemistry, 153(5), 617-630.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-KCNIP4 Recombinant Antibody (1A11) (CAT#: CBMAB-1593-CN)

Isotype control

For research use only. Not intended for any clinical use.

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