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Mouse Anti-KCNIP4 Recombinant Antibody (1A11) (CBMAB-1593-CN)

This product is a mouse antibody that recognizes KCNIP4 of human. The antibody 1A11 can be used for immunoassay techniques such as: WB, ELISA, IF.
See all KCNIP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A11
Antibody Isotype
IgG1, Κ
Application
WB, ELISA, IF

Basic Information

Immunogen
KCNIP4 (AAH32520, aa. 1-251) full length recombinant protein with GST tag.
Specificity
Human
Antibody Isotype
IgG1, Κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Potassium Voltage-Gated Channel Interacting Protein 4
Introduction
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. It modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner.
Entrez Gene ID
80333
UniProt ID
Q6PIL6
Alternative Names
CALP; KCHIP4
Function
Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435).
Modulates KCND3/Kv4.3 currents (PubMed:23576435).
Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440).
Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.
Biological Process
Protein localization to plasma membraneISS:UniProtKB
Regulation of potassium ion transmembrane transportISS:UniProtKB
Cellular Location
Cell membrane; Cytoplasm
Isoform 4: Endoplasmic reticulum
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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