Rabbit Anti-KCNIP4 Recombinant Antibody (CBLY1-051) (CBMAB-K0559-LY)

Name: Rabbit Anti-KCNIP4 Recombinant Antibody (CBLY1-051)
SKU: CBMAB-K0559-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBLY1-051

Application

WB, IP

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Potassium Voltage-Gated Channel Interacting Protein 4

Introduction

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Entrez Gene ID

Human	80333
Mouse	80334
Rat	259243

UniProt ID

Human	Q6PIL6
Mouse	Q6PHZ8
Rat	Q99MG9

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates KCND2 channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:11847232, PubMed:18957440, PubMed:23576435).
Modulates KCND3/Kv4.3 currents (PubMed:23576435).
Isoform 4 does not increase KCND2 expression at the cell membrane (PubMed:18957440).
Isoform 4 retains KCND3 in the endoplasmic reticulum and negatively regulates its expression at the cell membrane.

Biological Process

Protein localization to plasma membraneISS:UniProtKB
Regulation of potassium ion transmembrane transportISS:UniProtKB

Cellular Location

Cell membrane; Cytoplasm
Isoform 4: Endoplasmic reticulum

Jenkins, C. A., Kalmar, L., Matiasek, K., Mari, L., Kyöstilä, K., Lohi, H., ... & Ricketts, S. L. (2020). Characterisation of canine KCNIP4: A novel gene for cerebellar ataxia identified by whole-genome sequencing two affected Norwegian Buhund dogs. PLoS Genetics, 16(1), e1008527.

Su, Z. J., Wang, X. Y., Zhou, C., & Chai, Z. (2020). Down‐regulation of miR‐3068‐3p enhances kcnip4‐regulated A‐type potassium current to protect against glutamate‐induced excitotoxicity. Journal of Neurochemistry, 153(5), 617-630.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Mouse Anti-KCNIP4 Recombinant Antibody (1A11) (CAT#: CBMAB-1593-CN)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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