KDM2B

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]

Full Name

Lysine Demethylase 2B

Function

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645).
Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645).
Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099).
May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable)

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Embryonic camera-type eye morphogenesisISS:BHF-UCL
Forebrain developmentISS:BHF-UCL
Fourth ventricle developmentISS:BHF-UCL
Hindbrain developmentISS:BHF-UCL
Histone H2A monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K36 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Initiation of neural tube closureISS:BHF-UCL
Lateral ventricle developmentISS:BHF-UCL
Midbrain developmentISS:BHF-UCL
Midbrain-hindbrain boundary morphogenesisISS:BHF-UCL
Negative regulation of neural precursor cell proliferationISS:BHF-UCL
Negative regulation of neuron apoptotic processISS:BHF-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of cell growthIEA:Ensembl
Positive regulation of stem cell population maintenanceIEA:Ensembl
Protein demethylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
SpermatogenesisISS:BHF-UCL
Third ventricle developmentISS:BHF-UCL

Cellular Location

Nucleus, nucleolus; Nucleus; Chromosome