Mouse Anti-KDM2B Recombinant Antibody (6F6G11) (CBMAB-K0071-LY)
Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645).
Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099).
May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable)
Embryonic camera-type eye morphogenesisISS:BHF-UCL
Forebrain developmentISS:BHF-UCL
Fourth ventricle developmentISS:BHF-UCL
Hindbrain developmentISS:BHF-UCL
Histone H2A monoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K36 demethylationManual Assertion Based On ExperimentIDA:UniProtKB
Initiation of neural tube closureISS:BHF-UCL
Lateral ventricle developmentISS:BHF-UCL
Midbrain developmentISS:BHF-UCL
Midbrain-hindbrain boundary morphogenesisISS:BHF-UCL
Negative regulation of neural precursor cell proliferationISS:BHF-UCL
Negative regulation of neuron apoptotic processISS:BHF-UCL
Negative regulation of transcription by RNA polymerase IIISS:BHF-UCL
Positive regulation of cell growthIEA:Ensembl
Positive regulation of stem cell population maintenanceIEA:Ensembl
Protein demethylationManual Assertion Based On ExperimentIBA:GO_Central
Regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
SpermatogenesisISS:BHF-UCL
Third ventricle developmentISS:BHF-UCL
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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