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KLHL25

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Full Name
Kelch Like Family Member 25
Function
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIAC F4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIAC F4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIAC F4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Biological Process
Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Cul3-RING ubiquitin ligase complex: Cytoplasm; Cytosol
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Anti-KLHL25 antibodies

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Mouse Anti-KLHL25 Recombinant Antibody (1E9) (CBMAB-K1197-LY)

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Target: KLHL25
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1E9
Application*: E, WB
Datasheet SDS

Mouse Anti-KLHL25 Recombinant Antibody (1B7) (CBMAB-K1196-LY)

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Target: KLHL25
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1B7
Application*: E, WB, P, IF/IC, F
Datasheet SDS

Mouse Anti-KLHL25 Recombinant Antibody (13B459) (CBMAB-K1195-LY)

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Target: KLHL25
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 13B459
Application*: E, WB
Datasheet SDS

Mouse Anti-KLHL25 Recombinant Antibody (CBT818) (V2LY-0625-LY3245)

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Target: KLHL25
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT818
Application*: WB, E
Datasheet SDS

Mouse Anti-KLHL25 Recombinant Antibody (CBT3978) (V2LY-0625-LY2468)

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Target: KLHL25
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBT3978
Application*: WB
Datasheet SDS
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Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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