KLHL25

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Kelch Like Family Member 25

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIAC F4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIAC F4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIAC F4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cul3-RING ubiquitin ligase complex: Cytoplasm; Cytosol