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KLHL25

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Full Name

Kelch Like Family Member 25

Function

Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIAC F4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIAC F4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIAC F4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.

Biological Process

Protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of translational initiationManual Assertion Based On ExperimentIDA:UniProtKB
Ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Cul3-RING ubiquitin ligase complex: Cytoplasm; Cytosol

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Anti-KLHL25 antibodies

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Mouse Anti-KLHL25 Recombinant Antibody (1E9) (CBMAB-K1197-LY)

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Target: KLHL25

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 1E9

Application*: E, WB

Mouse Anti-KLHL25 Recombinant Antibody (1B7) (CBMAB-K1196-LY)

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Target: KLHL25

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 1B7

Application*: E, WB, P, IF/IC, F

Mouse Anti-KLHL25 Recombinant Antibody (13B459) (CBMAB-K1195-LY)

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Target: KLHL25

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 13B459

Application*: E, WB

Mouse Anti-KLHL25 Recombinant Antibody (CBT818) (V2LY-0625-LY3245)

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Target: KLHL25

Host: Mouse

Antibody Isotype: IgG

Specificity: Human

Clone: CBT818

Application*: WB, E

Mouse Anti-KLHL25 Recombinant Antibody (CBT3978) (V2LY-0625-LY2468)

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Target: KLHL25

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: CBT3978

Application*: WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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