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Mouse Anti-KLHL25 Recombinant Antibody (1B7) (CBMAB-K1196-LY)

This product is antibody recognizes KLHL25. The antibody 1B7 immunoassay techniques such as: ELISA, WB, IHC-P, IF/ICC, FC.
Host Species
Mouse
Application
ELISA, WB, IHC-P, IF/ICC, FC
Immunogen
Purified recombinant fragment of human KLHL25 expressed in E. Coli
Antibody Isotype
IgG2b
Specificity
Human
Clone
1B7
Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
Introduction
Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1): ubiquitination and subsequent degradation of hypophosphorylated EIF4EBP1 (4E-BP1) probably serves as a homeostatic mechanism to maintain translation and prevent eIF4E inhibition when eIF4E levels are low. The BCR(KLHL25) complex does not target EIF4EBP1 (4E-BP1) when it is hyperphosphorylated or associated with eIF4E.
Alternative Name
Kelch Like Family Member 25; Ectoderm-Neural Cortex Protein 2; Ectodermal-Neural Cortex 2; ENC-2; ENC2; BTB/POZ KELCH Domain Protein; Kelch-Like 25 (Drosophila); Kelch-Like Protein 25; Kelch-Like 25;
Entrez Gene ID
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For Research Use Only. Not For Clinical Use.
Cat CBMAB-K1196-LY
Conjugates
Size
Price $
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Second antibody and isotype control