MAP4K4

The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Full Name
Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4
Function
Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
Biological Process
Intracellular signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central
Negative regulation of apoptotic processManual Assertion Based On ExperimentIMP:CACAO
Negative regulation of cell-matrix adhesion1 PublicationNAS:ARUK-UCL
Neuron projection morphogenesisManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of ARF protein signal transductionBy SimilarityISS:ARUK-UCL
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:ARUK-UCL
Positive regulation of focal adhesion assemblyBy SimilarityISS:ARUK-UCL
Positive regulation of focal adhesion disassemblyBy SimilarityISS:ARUK-UCL
Positive regulation of GTPase activityBy SimilarityISS:ARUK-UCL
Positive regulation of keratinocyte migrationBy SimilarityISS:ARUK-UCL
Protein phosphorylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of JNK cascadeManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of MAPK cascadeManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Cytoplasm
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Anti-MAP4K4 antibodies

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Mouse Anti-MAP4K4 Recombinant Antibody (4A5) (CBMAB-A5228-LY)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 4A5
Application*: WB, E
Datasheet SDS

Mouse Anti-MAP4K4 Recombinant Antibody (2D4) (CBMAB-A5225-LY)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D4
Application*: WB, E
Datasheet SDS

Mouse Anti-MAP4K4 Recombinant Antibody (CBT674) (V2LY-0625-LY3351)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT674
Application*: WB, E
Datasheet SDS

Mouse Anti-MAP4K4 Recombinant Antibody (CBT675) (V2LY-0625-LY3350)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBT675
Application*: WB, E
Datasheet SDS

Mouse Anti-MAP4K4 Recombinant Antibody (CBT3123) (V2LY-0625-LY2220)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3123
Application*: WB
Datasheet SDS

Mouse Anti-MAP4K4 Recombinant Antibody (CBT3677) (V2LY-0625-LY2219)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3677
Application*: WB
Datasheet SDS

Mouse Anti-MAP4K4 Recombinant Antibody (4H9E7) (CBMAB-AO717LY)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H9E7
Application*: WB
Datasheet SDS

Mouse Anti-MAP4K4 Recombinant Antibody (3C7B5) (CBMAB-AO716LY)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C7B5
Application*: WB
Datasheet SDS

Rabbit Anti-MAP4K4 Recombinant Antibody (CBFYM-1556) (CBMAB-M1722-FY)

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Target: MAP4K4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Monkey, Mouse
Clone: CBFYM-1556
Application*: WB
Datasheet SDS

Rabbit Anti-MAP4K4 Recombinant Antibody (CBFYM-1555) (CBMAB-M1721-FY)

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Target: MAP4K4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYM-1555
Application*: P, F
Datasheet SDS

Mouse Anti-MAP4K4 Recombinant Antibody (CBFYM-1553) (CBMAB-M1719-FY)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYM-1553
Application*: WB, F
Datasheet SDS

Mouse Anti-MAP4K4 (AA 611-710) Recombinant Antibody (CBFYM-1552) (CBMAB-M1718-FY)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYM-1552
Application*: E, WB
Datasheet SDS

Mouse Anti-MAP4K4 (AA 400-500) Recombinant Antibody (4H9E7) (CBMAB-M1717-FY)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4H9E7
Application*: WB
Datasheet SDS

Rabbit Anti-MAP4K4 (C-terminus) Monoclonal Antibody (CBFYH-3293) (CBMAB-H3679-FY)

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Target: MAP4K4
Host: Rabbit
Specificity: Human
Clone: CBFYH-3293
Application*: IH, P
Datasheet SDS

Rabbit Anti-MAP4K4 Recombinant Antibody (D19H10) (CBMAB-H3678-FY)

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Target: MAP4K4
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Monkey
Clone: D19H10
Application*: WB
Datasheet SDS

Mouse Anti-MAP4K4 (AA 400-500) Recombinant Antibody (3C7B5) (CBMAB-H3677-FY)

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Target: MAP4K4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3C7B5
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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