MARCH5

MARCH5 is a ubiquitin ligase of the mitochondrial outer membrane that plays a role in the control of mitochondrial morphology by regulating mitofusin-2 (MFN2; MIM 608507) and DRP1 (DNM1L; MIM 603850) (Nakamura et al., 2006 [PubMed 16936636]).[supplied by OMIM

Full Name

membrane-associated ring finger (C3HC4) 5

Function

Mitochondrial E3 ubiquitin-protein ligase that plays a crucial role in the control of mitochondrial morphology by acting as a positive regulator of mitochondrial fission. May play a role in the prevention of cell senescence acting as a regulator of mitochondrial quality control. Promotes ubiquitination of FIS1, DNM1L and MFN1.

Biological Process

Negative regulation of cell aging Source: UniProtKB
Positive regulation of mitochondrial fission Source: UniProtKB
Protein autoubiquitination Source: UniProtKB
Protein localization to mitochondrion Source: UniProtKB
Protein polyubiquitination Source: UniProtKB
Regulation of mitochondrial fission Source: UniProtKB

Cellular Location

Endoplasmic reticulum
Endoplasmic reticulum membrane
Mitochondrion
Mitochondrion outer membrane
Note: Authors show that the protein can be detected in endoplasmic reticulum (PubMed:14722266). Authors (PubMed:16874301) show its presence only in mitochondria (PubMed:16874301).

PTM

Autoubiquitinated leading to degradation (short half-life).