MBD1

The protein encoded by this gene is a member of a family of nuclear proteins related by the presence of a methyl-CpG binding domain (MBD). These proteins are capable of binding specifically to methylated DNA, and some members can also repress transcription from methylated gene promoters. This protein contains multiple domains: MBD at the N-terminus that functions both in binding to methylated DNA and in protein interactions; several CXXC-type zinc finger domains that mediate binding to non-methylated CpG dinucleotides; transcriptional repression domain (TRD) at the C-terminus that is involved in transcription repression and in protein interactions. Numerous alternatively spliced transcript variants encoding different isoforms have been noted for this gene.
Full Name
MBD1
Function
Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone 'Lys-9' trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.
Biological Process
Negative regulation of transcription, DNA-templated Source: UniProtKB
Transcription by RNA polymerase II Source: ProtInc
Cellular Location
Nucleus
Nucleus matrix
Nucleus speckle
Other locations
Chromosome
Note: Nuclear, in a punctate pattern (PubMed:12711603). Associated with euchromatic regions of the chromosomes, with pericentromeric regions on chromosome 1 and with telomeric regions from several chromosomes (PubMed:10648624, PubMed:10454587).
PTM
Sumoylated, sumoylation may increase interaction with ATF7IP.
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Anti-MBD1 antibodies

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Rabbit Anti-MBD1 Recombinant Antibody (
10B10) (V2LY-0725-LY1370)

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Target: MBD1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 10B10
Application*: E, IF
Datasheet SDS

Mouse Anti-MBD1 Recombinant Antibody (2B10) (CBMAB-A5326-LY)

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Target: MBD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 2B10
Application*: WB, E
Datasheet SDS

Mouse Anti-MBD1 Recombinant Antibody (CBFYM-1798) (CBMAB-M1966-FY)

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Target: MBD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Mouse
Clone: CBFYM-1798
Application*: WB, E
Datasheet SDS

Mouse Anti-MBD1 (AA 415-508) Recombinant Antibody (CBFYM-1795) (CBMAB-M1963-FY)

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Target: MBD1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-1795
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-MBD1 (AA 291-586) Recombinant Antibody (CBFYM-1794) (CBMAB-M1962-FY)

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Target: MBD1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYM-1794
Application*: IH, WB
Datasheet SDS

Mouse Anti-MBD1 (AA 391-405) Recombinant Antibody (CBFYM-0016) (CBMAB-M0020-FY)

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Target: MBD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYM-0016
Application*: WB
Datasheet SDS

Mouse Anti-MBD1 Antibody (8BA25) (CBMAB-1414CQ)

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Target: MBD1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 8BA25
Application*: E, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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