MOCS3

Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]
Full Name
Molybdenum Cofactor Synthesis 3
Function
Plays a central role in 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions.
Biological Process
Mo-molybdopterin cofactor biosynthetic process Source: UniProtKB
Protein urmylation Source: GO_Central
tRNA thio-modification Source: UniProtKB
tRNA wobble position uridine thiolation Source: GO_Central
tRNA wobble uridine modification Source: UniProtKB
Cellular Location
Cytoplasm
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Anti-MOCS3 antibodies

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Mouse Anti-MOCS3 Recombinant Antibody (1C5-E8) (CBMAB-A5545-LY)

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Target: MOCS3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 1C5-E8
Application*: WB, E
Datasheet SDS

Mouse Anti-MOCS3 (AA 1-461) Recombinant Antibody (CBFYM-2462) (CBMAB-M2649-FY)

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Target: MOCS3
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYM-2462
Application*: WB
Datasheet SDS

Mouse Anti-MOCS3 (AA 1-461) Recombinant Antibody (CBFYM-0487) (CBMAB-M0615-FY)

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Target: MOCS3
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYM-0487
Application*: E, WB
Datasheet SDS

MOCS3 Matched Antibody Pair (745) (APMAB-745LY)

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Target: MOCS3
Specificity: Human
Datasheet SDS

MOCS3 Matched Antibody Pair (744) (APMAB-744LY)

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Target: MOCS3
Specificity: Human
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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