NAE1

The protein encoded by this gene binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]
Full Name
NEDD8 activating enzyme E1 subunit 1
Function
Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.
Biological Process
Mitotic DNA replication checkpoint signaling Source: UniProtKB
Neuron apoptotic process Source: UniProtKB
Protein modification by small protein conjugation Source: GO_Central
Protein neddylation Source: UniProtKB
Regulation of apoptotic process Source: UniProtKB
Regulation of neuron apoptotic process Source: UniProtKB
Signal transduction Source: ProtInc
Cellular Location
Cell membrane
Note: Colocalizes with APP in lipid rafts.
PTM
Ubiquitinated by TRIP12, leading to its degradation by the proteasome.
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Anti-NAE1 antibodies

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Mouse Anti-NAE1 Recombinant Antibody (4E8-H3) (CBMAB-A4595-YC)

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Target: NAE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E8-H3
Application*: E, WB
Datasheet SDS

Rabbit Anti-NAE1 Recombinant Antibody (D9I4Z) (CBMAB-N1072-WJ)

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Target: NAE1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat, Monkey, Cattle, Dog
Clone: D9I4Z
Application*: WB
Datasheet SDS

Mouse Anti-NAE1 Recombinant Antibody (CBWJN-0341) (CBMAB-N1070-WJ)

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Target: NAE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJN-0341
Application*: E, WB
Datasheet SDS

Mouse Anti-NAE1 Recombinant Antibody (1D12) (CBMAB-N1069-WJ)

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Target: NAE1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 1D12
Application*: WB
Datasheet SDS

Mouse Anti-NAE1 Recombinant Antibody (1B2) (CBMAB-N1068-WJ)

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Target: NAE1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: 1B2
Application*: WB
Datasheet SDS

Mouse Anti-NAE1 Recombinant Antibody (1E10) (CBMAB-N1066-WJ)

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Target: NAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E10
Application*: IH, WB
Datasheet SDS

Mouse Anti-NAE1 Recombinant Antibody (1E9) (CBMAB-N1065-WJ)

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Target: NAE1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1E9
Application*: WB
Datasheet SDS

Mouse Anti-NAE1 Recombinant Antibody (CBWJN-0942) (CBMAB-N0107-WJ)

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Target: NAE1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBWJN-0942
Application*: E, WB
Datasheet SDS

Human Recombinant NAE1 protein, His Tag (V2LY-0526-LY5687)

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Target: NAE1
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: 2-end
Tag: His Tag
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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